Stem Cell Research

Negative feedback loop controls SCF-KIT signaling pathway

Published in Immunotherapy Weekly, April 6th, 2005

A negative feedback loop controls the SCF-KIT signaling pathway.

"Activation of the KIT receptor tyrosine kinase contributes to the pathogenesis of several human diseases, but the mechanisms regulating KIT signaling have not been fully characterized.

"Here, we show that stem cell factor (SCF), the ligand for KIT, induces the interaction between KIT and Cbl proteins and their mutual degradation," wrote scientists from the United States.

"Upon SCF stimulation," wrote S. Zeng and coworkers at Columbia University, "KIT binds to and induces the phosphorylation of Cbl proteins, which in turn act as E3 ligases, mediating the...

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Source: Immunotherapy Weekly (2005-04-06)

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