Vaccine Development

Microemulsion systems for oral delivery of proteins characterized

Published in Immunotherapy Weekly, April 20th, 2005

Researchers have characterized of micro-emulsion systems using tocopheryl polyethylene glycol 1000 succinate as a surfactant for the oral delivery of protein drugs.

"Attempts were to develop microemulsion systems using medium chain triglyceride, deionized water, and TPGS as surfactant for the oral delivery of protein drugs or poorly water-soluble drugs. Phase diagrams were constructed to elucidate the phase behavior of systems composed of Captex 300 and water with D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) as main surfactant, polysorbates (Tween 20, Tween 40, Tween 60, and Tween 80) as adjuvant surfactants, and polyethylene glycols (PEG 400 and PEG...

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Source: Immunotherapy Weekly (2005-04-20)

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