Cytomegalovirus

Mutagenesis of cytomegalovirus glycoprotein attenuates viral growth

Published in Immunotherapy Weekly, May 18th, 2005

Site-directed mutagenesis of the carboxyl terminus of human cytomegalovirus glycoprotein B leads to attenuation of viral growth in cell culture.

"A viable human cytomegalovirus (HCMV) mutant was generated harboring a glycoprotein B (gB) in which the carboxyl-terminal amino acids DRLRHR (aa 885-900) were changed to AALREE. Characterization of the phenotype of the recombinant virus revealed significant reduction of infectious progeny release and only moderate reduction of viral DNA replication indicating its diminished specific infectivity," scientists in Germany and Australia report.

"This observation was in line with immunogold labeling of...

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Source: Immunotherapy Weekly (2005-05-18)

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