Arthritis

TNF-alpha-308 promoter polymorphism contributed to rheumatoid arthritis severity

Published in Immunotherapy Weekly, May 18th, 2005

Tumor necrosis factor (TNF)-alpha-308 promoter polymorphism might contribute to HLA alleles in the severity of rheumatoid arthritis (RA) in Mexicans.

"The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-alpha) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions -238 and -308 of TNF-alpha gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared to healthy controls (pC=.02,...

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Source: Immunotherapy Weekly (2005-05-18)

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