Malaria Vaccine

Glycosylphosphatidylinositol influence on malaria vaccines explored

Published in Immunotherapy Weekly, August 31st, 2005

Researchers report the influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5 in a recent issue of Vaccine.

"Immune responses induced to DNA vaccination vary considerably and depend on a variety of factors, including the physical form in which the antigen is expressed by target cells and presented to the immune system. Data on the effect of these factors will aid improved design of DNA vaccines and facilitate their further development. We examined the effect of different forms of surface anchoring on the immunogenicity of a DNA vaccine," investigators in Australia...

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Source: Immunotherapy Weekly (2005-08-31)

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