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Meningitis Vaccine

Porin A-specific antibody avidity after meningococcal disease reported

Published in Immunotherapy Weekly, August 31st, 2005

Researchers report porin A-specific antibody avidity in patients who are convalescing from meningococcal B disease.

"Porin A (PorA), which determines the serosubtype of Neisseria meningitidis, is the main antigen of a candidate vaccine against serogroup B meningococci, which has been shown to induce high-avidity antibodies in children. We characterized the immune response of children after convalescing from meningococcal infection with a serosubtype P1.7-2,4 strain. Acute- and convalescent-phase sera of 21 children with meningococcal septic shock caused by strains with PorA subtype P1.7-2,4 were collected," scientists in the Netherlands report.

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