Osteoarthritis

Chondrocyte cluster assay used to identify OA-related genes

Published in Immunotherapy Weekly, August 31st, 2005

A novel chondrocyte cluster assay has been used to identify osteoarthritis (OA)-related genes.

"Understanding altered gene expression in osteoarthritic cartilage can lead to new targets for drug intervention," according to scientists in the United States, who "established a functional assay based on chondrocyte cluster formation," a phenotype associated with OA, "to screen an OA cartilage gene library."

"Previous reports have demonstrated that normal chondrocytes grown in suspension culture maintain their chondrocytic phenotype; however, certain growth factors such as basic fibroblast growth factor (bFGF) will induce the cells to proliferate in tight...

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Source: Immunotherapy Weekly (2005-08-31)

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