Published in Immunotherapy Weekly, August 31st, 2005
"Understanding altered gene expression in osteoarthritic cartilage can lead to new targets for drug intervention," according to scientists in the United States, who "established a functional assay based on chondrocyte cluster formation," a phenotype associated with OA, "to screen an OA cartilage gene library."
"Previous reports have demonstrated that normal chondrocytes grown in suspension culture maintain their chondrocytic phenotype; however, certain growth factors such as basic fibroblast growth factor (bFGF) will induce the cells to proliferate in tight...
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