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Crohn Disease

CD19+ in intestinal mucosa may predict response to infliximab

Published in Immunotherapy Weekly, August 31st, 2005

CD19+ in intestinal mucosa may predict response to infliximab in Crohn disease.

"Infliximab is an effective treatment for Crohn's disease, yet about 30% of patients have a weak or no response. The aim of the study was to determine if the likelihood of a patient achieving complete remission 3 months after treatment with infliximab can be predicted from immunological parameters measured in peripheral blood and inflamed intestinal mucosa before the treatment. Twenty-five patients with Crohn's disease resistant to conventional therapy underwent treatment with infliximab," scientists writing in the journal Hepato-Gastroenterology reported.

"Samples...

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