Candidiasis Vaccine

C. albicans epitope protects against systemic candidiasis

Published in Immunotherapy Weekly, August 31st, 2005

Prophylactic vaccination with phage-displayed epitope of Candida albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice.

According to a study from China, "Epitope LKVIRK on 47 kDa of heat shock protein (Hsp) 90 of Candida albicans, corresponding to residues 396-391 of the Hsp90, is recognized by patients recovering from invasive candidiasis. The efficacy of hybrid phage displaying epitope LKVIRK in the N-terminal region of the major coat protein (pVIII) in inducing anti-invasive candidiasis immune response was studied in C57BI.J6 mice."

"Indirect phage-ELISA results demonstrated that the mice immunized...

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Source: Immunotherapy Weekly (2005-08-31)

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