Immunotherapy Weekly

HIV/AIDS-Herpes Simplex Virus Type 2 Coinfection - Treating HSV-2 in HIV-coinfected persons delays need for HAART

HIV/AIDS-Related Dementia - HIV-1 gp120 and Tat induce oxidative stress in brain endothelial cells

HIV/AIDS-Related Herpes Simplex Virus Type 2 - Macaque dendritic cells can become infected by herpes simplex virus type 2

Haemophilus Vaccine Development - Epiglottitis incidence reduced after Haemophilus influenzae vaccine

Haemophilus Vaccine Development - Hib vaccine failure linked to multiple copies of capsulation b locus

Head & Neck Cancer - Genes reveal lymph node micrometastasis in patients with oral cancer

Helicobacter Vaccine Development - Oral vaccine elicits response against Helicobacter pylori

Hepatitis C Virus - Alternate priming approaches enhance hepatitis C vaccine in rhesus macaques

Hepatocellular Cancer - Researchers publish new studies and findings in the area of hepatocellular cancer

Immunology - Coreceptor transcription analyzed, role of modulation revealed

Immunology - Host-residual invariant NK T cells attenuate graft-versus-host immunity

Immunology - Immune response to tuberculin protein in GATA-3-transgenic mice studied

Immunology - TCR alpha beta repertoire diversity of CD4+CD25+ regulatory T cells reported

Immunotherapy - Long-term control MTB infection mediated by dynamic immune responses

Infectious Disease - Amyloid fibers found in neurodegenerative disorders

Infectious Disease - Humans more likely than insects to spread disease in Gulf of Mexico area

Infectious Disease - In hurricane aftermath infectious disease threats are not from exotic diseases

Infectious Disease - Malformed prion proteins responsible for infections

Inflammation - Aspirin may downregulate inflammation and formation of homocysteine

Influenza - Highly pathogenic H5N1 viruses in ducks are a serious threat to humans/animals

Influenza - U.S. government buys vaccine, antivirals for potential influenza pandemic

Influenza Epidemiology - Need for effective influenza vaccine in infants demonstrated

Influenza Outbreaks - Influenza H3N2 viruses continue to drift from vaccine strains in Nepal

Influenza Vaccine Development - Method for nasal influenza vaccine delivery using chitosan developed

Influenza Vaccine Development - Neuraminidase-expressing DNAs protect against influenza virus infection

Influenza Vaccine Development - Respiratory vaccination of mice against influenza virus examined

Influenza Vaccine Efficacy - Influenza vaccines are safe and effficacious in HIV-positive patients

Influenza Vaccines - New findings in the area of influenza vaccines detailed

Information Technology - Patient reported outcome solution chosen by Asthmatx to collect trial data

Islet Transplantation - Viral immune regulation in pancreatic islet transplantation examined

Kidney Transplantation - Reports add new data to kidney transplantation research

Leishmaniasis Vaccine Development - T helper cell type in leishmaniasis vaccine discovery examined

Leukemia Vaccine Development - Receptor epitopes recognized by T cells of leukemia patients identified

Liver Transplantation - Living-donor liver transplantation suggested for hepatoblastoma

Lung Cancer - Paper addresses new vector system in treatment of models of lung cancer

Lymphoma - Ciprofloxacin affected cyclophosphamide pharmacokinetics in NHL patients

Malaria - Recent findings in malaria described

Malaria Outbreaks - Msp1 B-K1/varD genotype associated with severe malaria on French Guiana coast

Malaria Vaccine Development - Full-length cDNA libraries used to develop malaria vaccines

Malaria Vaccines - Research in malaria vaccines provides new insights

Medical Devices - Device company receives U.S. FDA clearance for MedStar

Melanoma - Positive data reported from phase II immunotherapy study in advanced melanoma

Melanoma Vaccine Development - Protection against melanoma found without autoimmune depigmentation

Melanoma Vaccines - Researchers describe findings in melanoma vaccines studies

Meningitis Vaccine Development - Investigational meningitis vaccine immunogenic in children

Meningitis Vaccine Development - Meningococcal outer membrane vesicle vaccine elicited immune response

Meningococcal Vaccines - Research add new data to meningococcal vaccines body of knowledge

Mergers & Acquisitions - GlaxoSmithKline to acquire biotech company

Metastasis - Classification of regional lymph node metastases from colon cancer reported

Microencapsulation - Release of DNA from dendriplexes encapsulated in PLGA nanoparticles

Mucosal Immunization - Coated nanoparticles for new mucosal vaccine delivery system developed

Myasthenia Gravis Vaccine Development - Vaccines against myasthenia gravis reviewed

Mycobacterium Tuberculosis - MTB growth inhibition in immunized or naive mice followed by stable infection

Nasal Polyps - Inflammatory mediators and eosinophilia of nasal polyposis studied

Nephrology - Apolipoprotein A-IV examined, kidney tissue localization defined

Neurodegeneration - Celastrol has promise as a neuroprotective agent for treatment of PD, HD

Neurogastroenterology - Caspase inhibition increases survival of transplanted CNS-NSC in gastro tract

Neurology - New research in the area of neurology detailed

Neuroscience - Tyr phosphatase zeta/beta studied, neuronal synaptic localization revealed

Oncology - Ara-C fever and infections occurred after high-dose Ara-C treatment

Ovarian Cancer - Researchers' data advance ovarian cancer research

Pain Management - Health Canada OKs Phase 2b trial of opioid inhalation formulation for acute pain

Pediatric Rheumatology - Hospital wins NIH pediatric rheumatology training grant

Pertussis Vaccine Development -  B. pertussis in countries with different vaccine policies analyzed

Pertussis Vaccines - New findings in the area of pertussis vaccines detailed

Physiology - Myonemes and membranelles studied, caltractin-related protein characterized

Physiology - Urea transporter UT-A2 studied, impaired urea accumulation revealed

Pneumococcal Vaccine Development - Pneumococcal infections in population with low HIV prevalence examined

Polio Vaccines - Researchers detail new studies and findings in the area of polio vaccines

Porphyromonas Vaccine Development - Vaccine effect on P. gingivalis infection is adjuvant-dependent

Prognostics - Wr-CRP is introduced as an alternate assay for detection of microinflammation

Prostate Cancer - Interference with Hedgehog-Gli signaling inhibits prostate cancer

Pseudomonas Vaccine Development - Immunization against Pseudomonas aeruginosa reviewed

Psoriasis - Animal model created to study psoriasis causes

Respiratory Medicine - Immune globulin treatment reduces incidence, severity of CVID

Respiratory Medicine - Multi-, binucleate cells may be biomarkers of inflammation in the lungs

Respiratory Syncytial Virus - Experts lead teleconference on safeguarding preemie health

Respiratory Syncytial Virus - G protein fragment and RSV epitope enhance immune responses

Rheumatoid Arthritis - Roche files first rheumatoid arthritis indication for MabThera in Europe

Ross River Disease Outbreaks - Various factors predict Ross River virus disease outbreaks

Rotavirus Vaccines - New findings in the area of rotavirus vaccines described

SARS - New findings in the area of SARS detailed

SARS Vaccine Development - Expression of SARS-CoV spike protein subunit elicits immune responses

Schistosomiasis Vaccine Development -  Schistosoma mansoni protein protects against schistosomiasis

Smallpox Vaccine Development - Vaccinia virus tropism determined by expression of virus receptor

Stem Cell Research - ANG II increases 2-deoxyglucose uptake in embryonic stem cells

Stem Cell Research - CD93 rapidly shed from surface of myeloid cells/soluble form detected in plasma

Stem Cell Research - Donor cell markers required to track differentiation potential of transgenic SCs

Stem Cell Research - Dual method used to expand embryonic stem cells

Stem Cell Research - Intron 5/6 promoter region of SHIP1 gene regulates expression in embryonic SCs

Stem Cell Research - Liver cells induce liver-specific gene expression in mesenchymal stem cells

Stem Cell Research - Musculin/MyoR expressed in kidney side population cells/regulates their function

Stem Cell Research - Nestin-positive MSCs differentiate into excitable neuron-like cells in vitro

Stem Cell Research - Neural stem cells potential source of oligodendrocytes for myelin repair

Stem Cell Research - Neuregulin-1 increases proliferation of neuronal progenitors from embryonic NSCs

Stem Cell Research - Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in BM stromal cells

Stem Cell Research - SDF-1 signals CXCR4+ cell mobilization/homing to kidney after ischemic injury

Stem Cell Research - TGF-beta1 modulates responses of CD34+ cord blood cells to SDF-1/CXCL12

Stem Cell Research - Tmod1 gene disruption compromises cardiomyocyte development in embryonic SCs

Stem Cell Research - Trafficking of normal SCs & metastasis of cancer SCs involve similar mechanisms

Stem Cell Research - bFGF supports undifferentiated embryonic SC growth without conditioned medium

Stem Cell Transplantation - Aldehyde dehydrogenase activity is a marker for the quality of HSCT grafts

Stem Cell Transplantation - Allogeneic stem cell transplantation promising treatment for NK-cell neoplasms

Stem Cell Transplantation - Poor nutritional status prior to SCT associated with increased hospital stay

Stem Cell Transplantation - Single dose pegfilgrastim as safe and effective as daily filgrastim injections

Stem Cell Transplantation - Transplanted bone marrow cells generate new brain cells

Systemic Lupus Erythematosus - Lupus group launches Spanish language campaign targeting Hispanic women

Tetanus Vaccine Development - Promoters for antigen expression in Salmonella developed

Tick-Borne Disease -  Ixodes scapularis cDNAs protective against infestation characterized

Tick-Borne Disease - Cross-reactive tick cement antigen used for broad-spectrum tick vaccine

Tick-Borne Disease - Methods for preparation of tick-derived stabilates compared

Tissue Engineering - Bone marrow-derived fibroblasts recruited into fibrotic lesions

Tissue Engineering - KSL cells have two different roles in muscle regeneration

Tissue Engineering - Research add new data to tissue engineering body of knowledge

Transplant Medicine - CD20+ B-cell clusters linked to reduced postrejection graft survival

Transplant Medicine - New findings in the area of transplant medicine described

Transplant Medicine - U.S. FDA approves Cobas AmpliScreen hepatitis B test

Transplantation Medicine - Complement proteins with mammalian vector enhances cell protection

Transplantation Medicine - Heterogeneous alterations in alloimmunity linked to immunization

Tuberculosis Diagnosis - Rheumatoid arthritis reduces response to purified protein derivative

Tuberculosis Therapy - Imipenem has antimycobacterial activity in MTB-infected patients

Tuberculosis Transmission - MTB transmission possible by close contact between ill and healthy dogs

Tuberculosis Vaccine Development - Proteomics identify membrane-associated proteins of M. tuberculosis

Tuberculosis Vaccine Development - Variant tricarboxylic acid cycle found in M. tuberculosis

Tuberculosis Vaccines - Recent findings in tuberculosis vaccines provide new insights

Vaccine Adjuvant - Role of adjuvants in development of mucosal vaccines reviewed

Vaccine Delivery - DNA vaccination strategy defined by monitoring of antigen expression

Vaccine Delivery - Ex vivo transduction of dermal tissue for protein delivery described

Vaccine Delivery - Lipid vesicles used to deliver bacterial protein antigen

Vaccine Development - Procedure for large-scale preparation of plasmid DNA developed

Vaccine Development - U.S. FDA approves Proquad, a one-shot MMR and chickenpox vaccine

Vaccine Efficacy - Household cost-benefits of sustainable childhood immunization examined

Vaccine Efficacy - Low T-cell proliferation and high viral load limit vaccine efficacy

Vaccine Efficacy - QPCR used to assign infectious potencies to adenovirus-based vaccines

Vaccine Safety - Criticism of vaccines on World Wide Web reviewed

Vaccine Vector - Influenza A virus vector expressing active IL-2 generated

Vaccine Vector - Virus RNA replicons elicit distinct humoral immunity

Vaccines Vector - Researchers' work adds to vaccines vector body of knowledge

Vector Development - Findings describe new data in vector development research

Vibrio Cholerae -  V. cholerae adheres to starch granules incorporated in rehydration solution

Vibrio Cholerae -  V. fluvialis and V. cholerae El Tor hemolysin gene similar

Virology - Antigenic stimulation reactivates replication of archived SIV genomes

Virology - Foamy virus Bet proteins inhibit innate antiretroviral defense factors

Virology - Nodavirus examined, RNA replicase protein A self-interaction revealed