Meningitis Vaccine
CD14 deficiency leads to early death in pneumococcal infections
Published in Immunotherapy Weekly, November 2nd, 2005
According to recent research from Switzerland, "CD14 is a myeloid receptor for bacterial cell membrane/wall components, for which we previously showed a strong induction in cerebrospinal fluid (CSF) during meningitis. Here, we studied CD14 function in murine Streptococcus pneumoniae meningitis by using wild-type (WT), CD14-/- mice, and WT mice pretreated with neutralizing anti-CD14 antibodies. Early polymorphonuclear leukocytes (PAIN) immigration was more pronounced in CSF of CD14-/- than of WT mice....
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Source: Immunotherapy Weekly (2005-11-02)
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