Immunotherapy Weekly

HIV/AIDS Prevention - Vaginal microbicide phase III trial underway, 10,000 women to be enrolled

HIV/AIDS Prognosis - APOBEC3G/CEM15 mRNA levels inversely associated with HIV viremia

HIV/AIDS Prognosis - HLA-B63 is associated with low HIV RNA

HIV/AIDS Therapy - Abacavir/lamivudine/zidovudine improves HAART adherence in HIV-1-infected patients

HIV/AIDS Therapy - HIV protease inhibitor ritonavir increases endothelial monolayer permeability

HIV/AIDS Therapy - Trials comparing therapies for HIV/AIDS, related Kaposi's sarcoma are urgently needed in sub-Saharan Africa

HIV/AIDS Topical Microbicide - Topically applied amphibian-derived antimicrobial peptides inhibit HIV infection

HIV/AIDS Vaccine Development - CD8⁺ lymphocytes do not protect against acute SIV superinfection

HIV/AIDS Vaccine Development - HIV trials feasible with fewer animals if subjects repeatedly challenged with low doses

HIV/AIDS Vaccine Development - HIV-1 Env clones developed for standardized assessments of vaccine-elicited neutralizing antibodies

HIV/AIDS Vaccine Development - Research collaboration formed to develop topical delivery of therapeutic DNA vaccines

HIV/AIDS-Related Atherosclerosis - HIV-1 Tat induces VCAM-1 expression in pulmonary artery endothelial cells

HIV/AIDS-Related Infection - Incidence of esophageal candidiasis in AIDS patients in Europe is declining

HIV/AIDS-Related Infection - Nocardiosis to be considered in HIV patients with low CD4 counts

HIV/AIDS-Related Infection - Oral lesions are indicators of infection in HIV/AIDS

HIV/AIDS-Related Kaposi Sarcoma - AIDS-Kaposi sarcoma patients treated with HAART have a high clinical response rate

HIV/AIDS-Related Lipodystrophy - Metformin improves lipid profiles in HIV-related lipodystrophy

Helicobacter Pylori - Probiotic supplementation improves tolerance to H. pylori eradication therapy

Hepatitis B Vaccine - Alaska Natives immunized at birth are protected against hepatitis B

Hepatitis B Virus - Membrane heparan sulfate interactions facilitate hepatitis B virus-induced cytokine production

Hepatitis B Virus - Vaccination reduces hepatitis B prevalence in U.S. children

Hepatitis C Complications - Hepatitis C is complicated by morphine withdrawal

Hepatitis C Vaccine - Spontaneous responders to hepatitis C viremia have expansive epitope recognition

Hepatitis C Vaccine Development - Epitope characterization paves the way for hepatitis C peptide-based vaccines

Hookworm Vaccine Development - Hookworm heme-binding glutathione transferase has vaccine potential

Human Papillomavirus - Humoral immune response recognizes a complex set of epitopes on HPV-6 L1 capsomers

Immunodeficiency - Natural killer cell-mediated cytotoxicity spawns liver failure

Immunology - MBL study shows how good cholesterol (HDLs) provide human immunity to certain parasites

Immunotherapy - Peripheral immunomodulatory treatment of autoimmune encephalomyelitis induces neurogenesis

Immunotherapy - Prior intrahepatic BEC malfunction event may drive mitochondrial autoimmune disease

Infections - Research in infections provides new insights

Infections - Toll-like receptor regulates cardiomyocyte hypertrophy triggered by Trypanosoma cruzi

Infectious Diseases - Disease susceptibility to tuberculosis is dependent on host genetic predisposition

Influenza - Antivirals and vaccines maker offers pandemic flu plans

Influenza - Majority of Americans with asthma not immunized against flu despite known risks

Kidney Transplantation - Equine polyclonal antibody induction may heighten PTLD risk

Leukemia Vaccine Development - Acute promyelocytic leukemia cells cleared by adaptive immune mechanisms

Liver Cancer Vaccine Development - Autoantibodies against tumor-associated antigens in liver cancer identified

Lymphoma - Adult lymphomas analyzed in Edo state, Niger Delta region of Nigeria

Lymphoma - Clinical features of primary cutaneous marginal zone B-cell lymphoma described

Lymphoma - Researchers report details of new studies and findings in the area of lymphoma

Malaria - HRP2 antigen levels remain elevated for at least 7 days after malaria treatment

Malaria Drugs - HIV-1 protease inhibitors have antimalarial activity

Malaria Vaccine - Binding hot spot for invasion inhibitory molecules on P. falciparum antigen identified

Malaria Vaccine - Polymorphisms in malaria T cell epitopes not selected by immune pressure

Malaria Vaccine - Protective human immunity is a vaccine discovery tool for falciparum malaria

Malaria Vaccine Development - Changes in host cell tropism limits efficacy of malaria vaccine

Malaria Vaccine Development - Model system for testing malaria vaccines developed

Medical Devices - Prosthetic replacement option for post-traumatic arthritis after distal radius fracture

Meningitis Vaccine Development - Anti-idiotypic antibody is candidate for meningitis vaccine

Meningitis Vaccine Development - Meningococci from invasive meningococcal disease cases in Canada characterized

Mumps Vaccine - Plaque reduction neutralization is sensitive, specific for wild-type mumps virus

Mycobacterium Avium - Antineutrophil cytoplasmic antibody vasculitis associated with M. avium intracellulare infection

Neurogenesis - HR6B is up-regulated by nerve growth factor and required for neurite outgrowth

Non-Small Cell Lung Cancer - Enrollment opens in Phase III study of treatment for non-small cell lung cancer

Oncology - Marrow-derived endothelial precursors rarely contribute to tumor vascularization

Oncology - Research add new data to oncology body of knowledge

Ophthalmology - Keratinocyte growth factor prevents oxidative stress damage in RPE cells

Osteoarthritis - Regular physical activity may strenghten knee cartilage

Pain Management - Intrathecal neostigmine induces anti-inflammatory activity via spinal M₂ receptor activation

Pediatric Vaccine - Electronic registries may allow children to receive late routine vaccinations

Personnel - Eugene A. Bauer steps down as dermatology company director

Pertussis Vaccine -  Bordetella parapertussis clearance from respiratory tract requires humoral and cellular immunity

Pertussis Vaccines - New research in the area of pertussis vaccines detailed

Pharmaceutical Research - RiVax maker provides business and clinical update; RiVax phase I trial complete

Pneumococcal Vaccines - Recent studies add new data to pneumococcal vaccines research

Product Licensing - Company expands bacterial cell expression technology license with Crucell

Product Licensing - Rabbit monoclonal antibody technology licensed for antibody development

Prognostics - Cell proliferation prognosticated clinical outcome of mantle cell lymphoma

Proteomics - Proteomics of rheumatology are analyzed

Radiation Therapy - Proteasome inhibition improved fractionated radiation treatment

Respiratory Papillomatosis Vaccine - Immune stimulation is not effective for treatment of papilloma

Rheumatoid Arthritis - Patient enrollment complete in study of the safety and efficacy of MM-093

Rickettsia Infection - Endothelial cells help recruit immune cells to inflammation site during Rickettsia infection

Rubella Vaccine - Complex regional pain syndrome type I reported after rubella vaccine

SARS - Reports advance knowledge in SARS research

SARS Coronavirus - Immunodominant epitopes identified on the membrane protein of SARS coronavirus

Scabies - HTLV-1 infection is an important co-factor related to Norwegian scabies in Peru

Seasonal Allergic Rhinitis - Cetirizine more effective than fexofenadine at 5-12 hours posttreatment

Smallpox Vaccines - Reports describe recent advances in smallpox vaccines research

Staphylococcus Vaccine - Conjugate vaccine elicits antibodies that protect against S. aureus infection

Stem Cell Research - Mesenchymal stem cells are present in the adult lung

Stem Cell Transplantation - Embryonic stem cell immunogenicity increases upon differentiation after transplantation

Stem Cell Transplantation - New research in the area of stem cell transplantation detailed

Streptococcal Vaccine - Antibodies to iron uptake ABC transporter lipoproteins promote phagocytosis of Streptococcus

Streptococcal Vaccine Development - Prospects for group A streptococcal vaccine reviewed

Transplant Medicine - Immunogenic response is the same in fresh and cryopreserved arterial homografts

Transplant Medicine - Kidney foundation recognizes London researcher Anthony Jevnikar for excellence

Transplant Medicine - Patients with de novo hepatitis after liver transplantation display overlap syndrome

Transplant Medicine - Stable mixed chimerism is required for the suppression of cellular rejection

Transplant Medicine - Study indicates steroid-free immunosuppression is safe in pediatric renal transplants

Trypanosoma Cruzi - DHEA enhances reduces level of Trypanosoma cruzi parasites

Tuberculosis - PCR is more cost-effective than Ziehl-Neelsen smear microscopy for TB diagnosis

Tuberculosis - Recurrent tuberculosis in HIV-infected children is common in a high-burden TB setting

Tumor Metastasis - Chondroitin sulfate addition to CD44H negatively regulates hyaluronan binding

Vaccine Adjuvant -  Salmonella flagellin component potentiates immune responses

Vaccine Development - Recombinant antibody libraries aid vaccine research

Vaccine Efficacy - Pneumococcal vaccine likely to fail in splenectomized cancer patients

Vaccine Efficacy - UV radiation modifies leukocyte and cytokine responses to vaccination

Vaccine Safety - Data mining methods on the Vaccine Adverse Event Reporting System database compared

Vaccines Delivery - Data advance knowledge in vaccines delivery research

Vaccinia Virus - NK cell migration early after vaccinia infection characterized

Vaccinia Virus - PCR is most sensitive for vaccinia virus detection in patient specimens

Vector Development - Findings describe new data in vector development research

Virology - Duck hepatitis B covalently closed circular DNA persists after transient infection

Virology - HIV and hepatitis C virus infection elicit similarities in natural killer cells

Virology - Hepatitis B virus pseudotypes elucidate early infection activity

Virology - Liver enzyme flares require scrutiny in HIV-HCV coinfected patients beginning therapy

Virology - Rab9 GTPase required for HIV-1, filovirus and measles virus replication

Virology - Researchers publish new studies and findings in the area of virology

X-Ray Exposure - Germ cell-transmitted alteration may be initiated by preconceptual maternal X-ray exposure