Apoptosis

Hsp90 inhibitors induced apoptosis of ZAP-70 and chronic lymphocytic leukemia

Published in Immunotherapy Weekly, November 30th, 2005

Heat-shock protein 90 (Hsp90) inhibitors induced the apoptosis of zeta-associated protein of 70 kDa (ZAP-70) and subsequently, chronic lymphocytic leukemia (CLL).

According to a study from the United States, "ZAP-70 is expressed in patients with aggressive CLL. We found that ZAP-70+ CLL cells expressed activated Hsp90 with high binding affinity for Hsp90 inhibitors, such as 17-allyl-amino-demethoxy-geldanamycin (17-AAG), whereas normal lymphocytes or ZAP-70-CLL cells expressed nonactivated Hsp90."

"Activated Hsp90 bound and stabilized ZAP-70, which behaved like an Hsp90 client protein only in CLL cells. Treatment with Hsp90 inhibitors such as 17-AAG...

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Source: Immunotherapy Weekly (2005-11-30)

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