Oncology
Mast cell heparin uses fibroblasts to staunch tumor cell growth
Published in Immunotherapy Weekly, November 30th, 2005
"The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts. We first immunostained a wide variety of human cancers for the presence of degranulated mast cells," scientists in the United States report.
"In a subsequent series of controlled in vitro experiments, we then co-cultured UACC-812 human breast cancer cells with normal fibroblasts in the presence or absence of different combinations and doses of mast cell tryptase, mast...
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Source: Immunotherapy Weekly (2005-11-30)
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