DNA Vaccine

Method to deliver plasmid DNA into cell nucleus developed

Published in Immunotherapy Weekly, November 30th, 2005

Scientists have developed a method for the targeted delivery of plasmid DNA into the nucleus of cells via nuclear localization signal peptide conjugated to DNA intercalating bis- and trisacridines.

According to recent research published in the journal Bioconjugate Chemistry, "Efficient nuclear targeting via nonviral delivery of DNA is still an unmet challenge in gene therapy. We have synthesized a novel 9-aminoacridine amino acid monomer that conveniently allows multiple acridines to be incorporated into peptide conjugates."

"In particular we have prepared bis-and trisacridine conjugates of nuclear localization signal peptide (NLS)...

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Source: Immunotherapy Weekly (2005-11-30)

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