Published in Immunotherapy Weekly, November 30th, 2005
According to recent research published in the journal Bioconjugate Chemistry, "Efficient nuclear targeting via nonviral delivery of DNA is still an unmet challenge in gene therapy. We have synthesized a novel 9-aminoacridine amino acid monomer that conveniently allows multiple acridines to be incorporated into peptide conjugates."
"In particular we have prepared bis-and trisacridine conjugates of nuclear localization signal peptide (NLS)...
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