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Immunotherapy Weekly

Susan Hasty, Publisher
Table of Contents . . . February 8th, 2006
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Immunotherapy Weekly | Other Publications

Allergy & Immunology - Immunotherapy for peanut allergy is getting closer to reality

Arthritis Pathogenesis - Candida albicans cell wall glucan promotes autoimmune arthritis

Autoimmune Disease - Researchers identify infection-fighting protein that signals immune system to attack

Immunotherapy - U.S. FDA approves first subcutaneous immunoglobulin replacement therapy

Leishmaniasis - BPQ-OH inhibits L. amazonensis growth, may help development of anti-Leishmania agents

Acute Bacterial Sinusitis - Biopharma company submits NDA for Orapem to treat respiratory tract and skin infections

Adenocarcinomas - COX-2 is expressed in stromal myofibroblasts surrounding colon adenocarcinomas

Adenovirus Vector - Viral vector mitigates neutralization by antiviral antibodies

Alcoholism - New automated method measures total antioxidant response in nonalcoholic steatohepatitis

Allergy & Immunology - Cytomegalovirus infection inhibits immune responses generated against P. carinii

Allergy & Immunology - Immunoglobulin rBet v1 G4-antibodies may modulate allergic rhinoconjunctivitis

Allergy & Immunology - Indoor allergens often present in home nebulizers

Allergy & Immunology - PKR plays critical role in immune response regulation to mycobacterial infection

Allergy & Immunology - PreHistin approval process to be conducted by OTC division of U.S. FDA

Allergy & Immunology - Toll-like receptor ligands act as adjuvants in allergen-specific immunotherapy

Amyotrophic Lateral Sclerosis - Bcl-_X L gene transfer is neuroprotective in models of motor neuron disease

Anthrax Vaccine - Anthrax spore vaccines based on toxin components have been developed

Apoptosis - HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis

Apoptosis - JNK activation contributes to DP5 induction and apoptosis after spinal cord injury

Arthritis - Biopharma company selects contract research organization to support phase IV arthritis program

Arthritis - Diclofenac gel reported effective and safe for relief of symptoms of knee osteoarthritis

Arthritis - Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis

Arthritis - New strategies help physicians make early diagnosis of spondyloarthritis

Arthritis - Vioxx-like drugs may still be best treatment option, study suggests

Asthma - Acute asthma treatment with levalbuterol in the ED resulted in higher patient discharge rates

Asthma - Growth factor interactions may compel remodeling in the asthmatic airway

Asthma - Study shows up to 15% of adult asthma cases in the United States are related to work

Atherosclerosis Vaccine - Apo B-100-related epitope reduces atherosclerosis and plaque inflammation

Avian Influenza - Bird flu infections in humans prompt new vaccine studies

Awards - U.S. NIH NIAID awards 2-year grant for development of influenza A virus vaccine

Bacteriology - Toll-like receptors are sentinels of host defense against bacteria

Baculovirus - Study characterized disassembly of structurally modified viral nanoparticles

Bariatric Surgery - Obesity surgery on the rise, especially among youth

Bioterrorism - Pharma firm to develop therapy for acute radiation syndrome

Body Piercing - Infections resulting from body piercing require fluoroquinolone for treatment

Bone Marrow Metastases - Tc-99m-MIBI used to detect bone marrow metastases in childhood solid tumors

Bordetella Vaccine - Mechanism of clearance of Bordetella from lungs requires TLR4

Breast Cancer - Older age linked to lower risk of lymph node metastasis in breast cancer

Breast Cancer - Researchers publish new studies and findings in the area of breast cancer

Breast Cancer Vaccine - Livin may be a major breast cancer antigen

Cancer Prevention - Green tea polyphenols avert ultraviolet radiation-induced skin cancer

Cancer Therapy - No increased efficacy seen in trial of low-dose total body irradiation for melanoma

Cancer Therapy - Research add new data to cancer therapy body of knowledge

Cancer Therapy - WX-G250 plus LD-IL-2 provides better outcome in renal cell carcinoma patients

Cancer Vaccines - Findings in cancer vaccines provide new insights

Cancer Vaccines - Researchers provide details of new studies and findings in the area of cancer vaccines

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Cervical Cancer - Recent findings illuminate research in cervical cancer

Chemotherapy - U.S. FDA approves EMEND for the prevention of nausea and vomiting associated with chemotherapy

Chickenpox Vaccine - Epidemiology of chickenpox is changing in Alberta

Chickenpox Vaccine - Lack of funding is limiting varicella vaccine coverage in Australia

Chlamydia Vaccine - Vaccination of newborn mice protects against Chlamydia trachomatis

Clarithromycin - Clarithromycin extended-release is an efficacious antibacterial option

Clinical Trials - Peg-Intron maintenance study in patients coinfected with hepatitis C and HIV initiated

Clinical Trials - Preliminary positive results from study of rheumatoid arthritis treatment reported

Collaborations - Agreement allows AstraZeneca to use TAXIScan technology

Collaborations - Pharma companies announce research alliance and licensing model for inflammatory disease products

Collaborations - Pharma company earns milestone payment from Organon collaboration

Contraceptive Vaccine - Adverse reactions to Freund's-adjuvanted immunocontraceptives were found in domestic cats

Cystic Fibrosis Therapy - Model for cystic fibrosis gene therapy has been developed

DNA Research - Skeletal muscle gene expression is enhanced by a polymer excipient Pluronic P85

DNA Vaccine - CD4+ T cell-independent DNA vaccine shows promise against opportunistic infections

Dengue Vaccine - Recombinant yellow fever 17D-dengue type 2 virus shows promise for dengue fever vaccine

Dermatology - Osteoporosis risk not being addressed in patients on glucocorticoid therapy

Diabetes Therapy - Hepatic insulin gene therapy prevents deterioration of vascular function

Diabetes Therapy - Researchers' data advance diabetes therapy research

Diabetes Therapy - Researchers' findings advance diabetes therapy research

Diabetes Vaccine - Nasal vaccine against autoimmune diabetes has been developed

Diagnostics - New test results for Streptococcus mutans consistent with data from culture-based products

Disease Associations - Withdrawal of bisphosphonates not recommended for necrosis of the jaws

Drug Development - Phase III development of lupus drug to start in spring 2006

Drug Research - Anti-endoglin antibody blocks angiogenesis and achieves expected pharmacokinetics in monkeys

Drug Safety - Lumiracoxib treatment effective and well-tolerated

Facilities - Pharma company completes the sale of its head office for $2.9 million

Finance - Biopharma completes debt financing to fund commercial manufacturing facility

Finance - Immunotherapy company secures additional $4.1 million

Follicular Lymphoma - Reactive germinal centers in follicular lymphoma indicated limited disease stage

Gastroenterology - TGDP levels may predict response in azathioprine-treated patients with Crohn disease

Gene Delivery - Thermo-responsive polymers act as gene delivery vectors

Gene Delivery - Ultrasound is key factor in achieving nuclear DNA localization for gene delivery

Gene Therapy - AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy

Gene Therapy - Simian lentiviral vector provides stable transduction of monocytes

Genetics & Genomics - IGS sequence analyses delineates C. neoformans and C. gattii at genotypic levels

HIV Detection - HIV type 1 DNA sequence can be detected using plasmonics nanoprobes

HIV-2 Pathogenesis - HIV-2 has more open and accessible V3 domain than HIV-1 due to glycan packing differences

HIV/AIDS Adverse Drug Reaction - mtDNA or lactate/pyruvate ratio poor markers of NRTI-associated mitochondrial toxicity

HIV/AIDS Behavioral Medicine - Condom use among youth varies according to whether partner is casual or steady

HIV/AIDS Behavioral Medicine - Men who pay women for sex have higher rates of STIs and low HIV testing levels

HIV/AIDS Behavioral Medicine - Optimistic HIV/AIDS perception leads to unprotected sex among men who have sex with men

HIV/AIDS Behavioral Medicine - Seasonal work migration and unsafe sex practices facilitate HIV spread in China

HIV/AIDS Diagnostics - Cobas Amplicor HIV-1 Monitor 1.5 and Versant HIV-1 RNA 3.0 assays compared

HIV/AIDS Diagnostics - Indeterminate rates for HIV genotyping are higher with LiPA compared with sequencing tests

HIV/AIDS Disease Control - Postexposure prophylaxis in Kenya raises specific concerns for childhood rape management

HIV/AIDS Drug Adherence - Pharmacist consultation educates HIV/AIDS patients and improves HAART adherence

HIV/AIDS Drug Adherence - Risk factors for HAART nonadherence in Brazil determined

HIV/AIDS Drug Development - Bifunctional HIV-1 inhibitors simultaneously block CD4 and CCR5 receptors

HIV/AIDS Drug Interaction - Ritonavir increases systemic exposure of prednisolone

HIV/AIDS Drug Resistance - Different HAART resistance patterns occur in responders and nonresponders

HIV/AIDS Drug Resistance - Enfuvirtide genotypic and phenotypic resistance rapidly disappears after discontinuation

HIV/AIDS Drug Resistance - HIV-1 drug resistance mutations increasing in Thailand

HIV/AIDS Drug Resistance - Mutation accumulation rate not associated with HIV RNA during stable HAART regimen

HIV/AIDS Drug Resistance - Previously unreported HIV-1 RT mutations associated with NRTI/NNRTI phenotypic resistance

HIV/AIDS Drug Resistance - Recent HIV-1 seroconverters more likely to have transmitted drug resistance

HIV/AIDS Epidemiology - Determination of gag and env subtypes of HIV-1 detected among injecting drug users

HIV/AIDS Epidemiology - Different patient population accounts for increased AIDS incidence in France

HIV/AIDS Epidemiology - Frequency of HIV/AIDS protective SDF1-3'A gene high among blood donors in Crete

HIV/AIDS Epidemiology - HIV-1 infection risk associated with SDF1 polymorphism and CXCR4 variation in South Africa

HIV/AIDS Epidemiology - HIV-1 subtype C is the predominant strain in southern Brazil

HIV/AIDS Epidemiology - Perinatal HIV transmission rate decreased in Sao Paulo

HIV/AIDS Fitness & Wellness - Increased trunk/limb fat ratio associated with adverse metabolic parameters after HAART

HIV/AIDS Genetics & Genomics - Genetic variation pattern at CCR5-Delta 32 consistent with neutral evolution

HIV/AIDS HAART - Archived resistant HIV linked to sequences before HAART interruption

HIV/AIDS HAART - GNB3 C825T polymorphism associated with short-term success of HAART treatment

HIV/AIDS HAART - HDL and LDL cholesterol levels increase in children on HAART

HIV/AIDS HAART - HIV RNA sustained below 20 copies/mL may prevent 184V mutation in CD4 cell DNA

HIV/AIDS HAART - Tenofovir DF salvage therapy well-tolerated and effective in pediatric HIV/AIDS

HIV/AIDS HAART - Viral load response to HAART independently predicts new AIDS event in late stage AIDS

HIV/AIDS HAART Failure - HAART interruption and resistance mutation emergence causes virological failure

HIV/AIDS Healthcare - Integrated management program facilitates care and treatment of children undergoing HAART

HIV/AIDS Healthcare Access - Community-based program provides meals as well as treatment for HIV-related complications

HIV/AIDS Orphans - HIV positivity or losing a parent to AIDS increases institutionalization in Brazil

HIV/AIDS Pathogenesis - Exogenous IL-7 may be of benefit during pathogenic SIVmac and HIV infection

HIV/AIDS Pathogenesis - Findings in HIV/AIDS pathogenesis provide new insights

HIV/AIDS Pathogenesis - New findings in the area of HIV/AIDS pathogenesis detailed

HIV/AIDS Pathogenesis - New research in the area of HIV/AIDS pathogenesis detailed

HIV/AIDS Pathogenesis - Researchers publish new studies and findings in the area of HIV/AIDS pathogenesis

HIV/AIDS Prevention - Majority of HIV-infected pregnant women lost to follow-up in prevention program in Malawi

HIV/AIDS Preventive Medicine - Multiple strategies needed to manage the pediatric AIDS epidemic in South Africa

HIV/AIDS Therapy - Researchers report details of new studies and findings in the area of HIV/AIDS therapy

HIV/AIDS Transmission - Real-time RT-PCR and bDNA correlate for HIV-1 RNA quantitation in breast milk

HIV/AIDS Vaccine - Cells from lentiviral-transduced CD34+ cells inhibited SHIV virus replication

HIV/AIDS Vaccine - Coreceptor-based anti-HIV strategy suppressed multiclade HIV-1 infections

HIV/AIDS Vaccine - HIV peptides in PLG microparticles enhance mucosal and systemic immune responses

HIV/AIDS Vaccine - HIV-1 vaccine induces potent immune responses by needle-free intradermal delivery

HIV/AIDS Vaccine - Lack of awareness must be addressed to ensure adequate number of vaccine trial volunteers

HIV/AIDS Vaccine - Plasmid DNA and adenovirus vector with type 35 fiber protects against HIV

HIV/AIDS Vaccines - Recent studies add new data to HIV/AIDS vaccines research

HIV/AIDS Vaccines - Studies advance knowledge in HIV/AIDS vaccines research

HIV/AIDS-Associated Lipodystrophy - Insulin resistance mechanisms enhance type 2 diabetes risk in HIV lipodystrophy

HIV/AIDS-Related Cancer - Systemic non-Hodgkin lymphoma prevalent in HIV/AIDS patients in Lima

HIV/Tuberculosis Coinfection - Data advance knowledge in HIV/Tuberculosis coinfection research

Haemophilus Vaccine - Hib conjugate vaccine is less effective in HIV-infected African children

Hepatitis B Virus - Naive antibody phage library contains HBV neutralizing antibody fragments

Hepatitis B Virus - Pre-emptive lamivudine treatment is warranted in heart transplant patients with chronic hepatitis B

Hepatitis C Virus - Hepatitis C virus protease functions in evasion of innate immunity

Hepatitis E Virus - Hepatitis E virus may be a zoonotic infection in pigs

Hip Replacement - Birmingham resurfacing prosthesis doesn't appear to raise femoral neck fracture risk

Hodgkin Disease - Combined-modality therapy resulted in local control of Hodgkin Disease

Hodgkin Disease - Successful ambulatory treatment of Hodgkin disease in Iranian children reported

Immune Disorders - Patients now surviving once-fatal X-linked agammaglobulinemia

Immunology - Cross-linking is needed for T cell co-stimulation activity of trimeric CD137L

Immunology - Lipopeptide structure determines TLR2 dependent cell activation level

Influenza - Anti-4-1BB and anti-ICOS synergistically activate CD4 and CD8 T cells

Influenza - Survey shows Americans underestimate severity of the flu

Influenza Vaccine - Adverse events are more likely when influenza vaccine is used inconsistent with labeling

Influenza Virus - Report outlines EU regulations for eradication and control of poultry diseases

Intraocular Lymphoma - Ifosfamide or trofosfamide used to treat patients with intraocular lymphoma

Kaposi Sarcoma-Associated Herpesvirus - Cigarette smoke concentrate inhibits KSHV infection

Large-Cell Lymphoma - HIV-DLCL patients share nearly similar outcomes to de novo lymphoma patients

Legal Issues - British Columbia court completes hearing on biopharm company's spin-out plans

Leishmaniasis Vaccines - Findings describe new data in leishmaniasis vaccines research

Leukemia - Abnormal phenotypic features typical of T-LGL leukemia may hold diagnostic value

Leukemia - New findings in the area of leukemia described

Liposomes - pH-sensitive peptide improves transfection efficiency of liposomes

Liver Transplant - Orthotopic liver transplantation improves outcome in HIV-positive patients

Lung Cancer - Variations of IL-6 and IL-10 levels during 3D-CRT used in lung cancer prognosis

Lymphoid Neoplasms - Protein expression pattern used to distinguish different lymphoid neoplasms

Lymphoma - Radiologic morphology of low-grade primary CNS lymphoma described

Lymphoproliferative Diseases - Various lymphoproliferative diseases classified

MALT Lymphoma - Patients with mucosa-associated lymphoid tissue lymphoma treated by oxaliplatin

Mantle Cell Lymphoma - Hypersensitivity to mosquito bites might indicate mantle cell lymphoma

Melanoma Vaccine - Study finds evidence for immunological tolerance against authochthonous melanomas

Melanoma Vaccines - Research in melanoma vaccines provides new insights

Meningitis Vaccine - Analysis of Neisseria meningitidis isolates reveals strains related to hypervirulent lineages

Meningitis Vaccine - Serogroup B Neisseria meningitidis vaccines are focus of review

Moneypox Risk Factors - Clinical characteristics of human monkeypox are the focus of review

Multiple Sclerosis Therapy - Inhibitor of alpha₄ integrin suppressed allergic encephalomyelitis

Non-Hodgkin Lymphoma - Fast-track status granted for new treatment for B-cell follicular non-Hodgkin lymphoma

Non-Hodgkin Lymphoma - Organochlorine chemicals in plasma related to risk of non-Hodgkin lymphoma

Non-Hodgkin Lymphoma - Prognostic factors in central nervous system non-Hodgkin lymphoma identified

Obesity Complications - Boys with high body masses have an increased risk of developing asthma

Oligonucleotides - CpG-oligodeoxynucleotide alters immune responses when applied to skin

Oncology - Histone deacetylase inhibitors arrest VEGF production and stop human mantle cell lymphoma

Osteoarthritis - Study finds no difference between intra-articular and oral tenoxicam for osteoarthritis

Outbreak - Limited measles outbreak is reported in highly vaccinated U.S. boarding school

Pediatric Vaccine - High proportion of children in Germany do not have adequate vaccine protection

Personnel - Asthma management company appoints Richard A. Lotti as president and CEO

Personnel - Former United States Marine Corps assistant commandant Gen. Richard Neal joins board

Personnel - Nutraceuticals company establishes scientific advisory board

Pertussis Vaccine - Study examined Bordetella pertussis antibody levels in children with asthma

Pertussis Vaccine - Toxin inhibits neutrophil recruitment to delay B. pertussis clearance

Pharmaceutical Research - Center of Excellence in Infectious Disease and Biodefense launched

Pneumococcal Vaccine - Invasive pneumococcal disease is declining in U.S. elderly

Pneumonia - Antibiotic resistance is returning pneumonia to a public health concern

Product Licensing - Cancer immunotherapeutic licensed from Memorial Sloan-Kettering Cancer Center

Psoriasis - U.S. FDA approves a once-daily therapy for treatment of psoriasis

Rabies Vaccine - Glycoprotein-mediated apoptosis limits spread of rabies viruses

Rabies Vaccine - Space-time cluster of adverse events is associated with canine rabies vaccine

Rheumatoid Arthritis - A composite index visual analog scale is useful for comparative studies of rheumatoid arthritis

Rheumatoid Arthritis - Interleukin-17 stimulates synoviocyte production of vascular endothelial growth factor

Rheumatoid Arthritis - Recombinant tumor necrosis factor produces improvement in rheumatoid arthritis

Rheumatology - ELR+ CXC chemokines display differential profiles in patients with proinflammatory disorders

Rotavirus Vaccine - No link was found between rotavirus vaccine and intussusception in Honolulu

Rubella Vaccine - Matrix models for childhood infections have been applied to rubella and mumps

Smallpox Vaccine - Modified vaccinia virus Ankara protein acts with viral protein to block apoptosis

Smallpox Vaccine - Report describes adverse events linked to smallpox vaccine in U.S.

Smallpox Vaccine - Smallpox fusion proteins cross-react with neutralizing antibodies

Smallpox Vaccine - Vaccinia K1L protein mediates host-range function in RK-13 cells via ankyrin repeat

Stem Cell Research - Mesenchymal stem cells differentiate into tenocytes by bone morphogenetic protein gene transfer

Surgical Technology - Fibroid polyp in colon successfully treated by endoclip-assisted endoscopic polypectomy

Tick-Borne Disease - Tick antigen vaccine controls Ixodes scapularis adult infestations

Transplant Medicine - Findings in transplant medicine provide new insights

Transplant Medicine - Recent findings in transplant medicine described

Transplant Medicine - Recent findings in transplant medicine provide new insights

Transplantation Biology - Prenatal inoculation with adult bone marrow produces acceptance of renal allografts

Tuberculosis Vaccine - BCG vaccine causes changes in peripheral blood T cell numbers in infants

Tuberculosis Vaccine - DNA vaccines against TB elicit efficient, protective immune responses

Tuberculosis Vaccine - Frequency of IFN-gamma-producing cells correlates with adjuvant enhancement of BCG vaccine

Tuberculosis Vaccine - Researchers examine strain-specific mycobacterial lipids and immunity to TB

Tuberculosis Vaccine - Vaccine induces cytokine responses in guinea pig model of pulmonary TB

Tuberculosis Vaccines - Recent findings illuminate research in tuberculosis vaccines

Tuberculous Meningitis - Clinical characteristics predictive of poor outcome in tuberculous meningitis

Typhoid Vaccine - Chinese typhoid vaccine appears effective

Vaccine Adjuvant - Low-toxicity MPL and RC529 are efficient adjuvants for CD4+ T cells

Vaccine Adjuvant - Melatonin finds use as vaccine agent

Vaccine Adjuvant - Rb1 fraction of ginseng elicits balanced Th1 and Th2 immune response

Vaccine Development - Mucosal effector memory T cells are focus of review

Vaccine Efficacy - Mucosal vaccines are improved by induction of innate immunity

Vaccine Efficacy - Report focuses on maximizing statistical power in group-randomized vaccine trials

Vaccine Safety - Pneumococcal vaccination is safe in patients with systemic lupus erythematosus

Vaccine Vector - Method is developed to produce pseudotyped rAAV vectors using baculovirus expression system

Vaccine Vector - Study examined osmolality effect of serum-free media upon adenovirus production

Vaccines Vector - Studies advance knowledge in vaccines vector research

Vaccinia Virus Vaccine - Study examined substrate specificity of vaccinia virus thymidylate kinase

Vector Development - HSV-1 thymidine kinase delivered by HIV-based virus-like particles induced cell death

Vector Development - Polyomavirus EGFP-pseudocapsids introduce proteins and peptides into mammalian cells

Vector Development - Stable transgene expression is driven by promoter in HSV-1 vector

Virology - Data advance knowledge in virology research

Virology - Researchers' work adds to virology body of knowledge

West Nile Virus - Mutation that protects against HIV infection may raise risk of West Nile virus

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