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Immunotherapy Weekly

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Allergy & Immunology



Toll-like receptor ligands act as adjuvants in allergen-specific immunotherapy



February 8th, 2006

Toll-like receptor ligands act as adjuvants in allergen-specific immunotherapy.

"Allergen-specific immunotherapy (SIT) leads to long-term amelioration of T-helper type 2 (Th2)-mediated allergic symptoms and is therefore recommended as a first line therapy for allergies. The major disadvantage of SIT is its low efficiency, requiring treatment over years. In this study, we evaluated the potential of Toll-like receptor (TLR) ligands to facilitate Th1-type immune responses," researchers in Switzerland and the United States report.

"The immunogenicity and therapeutic potential of the major bee venom allergen phospholipase A2 (PLA2) combined with various...


Source: Immunotherapy Weekly (2006-02-08)

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