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Amyotrophic Lateral Sclerosis

Bcl-_X L gene transfer is neuroprotective in models of motor neuron disease

Scientists writing in the journal Muscle and Nerve report, "Recent work implicates excitotoxicity-induced apoptosis as the mechanism triggering motor neuron death in amyotrophic lateral sclerosis (ALS). Our laboratory has previously utilized glutamate excitotoxicity in vitro to study this process. The present experiment tests whether overexpression of the gene for Bcl-_X L can inhibit excitotoxicity in this model system."

To track Bcl-_X L expression, the gene for green fluorescent protein (GFP) was inserted...

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