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Apoptosis
JNK activation contributes to DP5 induction and apoptosis after spinal cord injury
February 8th, 2006
According to recently published research from the United States, c-Jun N-terminal kinase (JNK) activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury (SCI). "Growing evidence suggests that cells undergo apoptosis after SCI. However, little is known about the early events that trigger apoptosis in the contused cord," wrote K.J. Yin and colleagues, Washington University. "The BH3-only subfamily of proapoptotic regulators (e.g., bim, bad, and dp5) is recognized as initiators of the apoptotic cascade, and is subject to stringent control, both at the transcriptional and post-translational level. In the current study,...
Source: Immunotherapy Weekly (2006-02-08)
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