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Arthritis
Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis
February 8th, 2006
Research from the Netherlands has documented that naive transgenic T cells expressing cartilage proteoglycan (PG)-specific TCR induce arthritis upon in vivo activation. "PG-induced arthritis (PGIA), a murine model for rheumatoid arthritis (RA), is driven by antigen (PG)-specific T and B cell activation," wrote S.E. Berlo and colleagues, University of Utrecht. "In order to analyze the pathogenic role of antigen-specific T cells in the development of autoimmune arthritis, we have generated a transgenic (Tg) mouse: The CD4+ T cells of this TCR-5/4E8-Tg line express a functional T cell receptor (TCR) composed of the V alpha 1.1 and V beta 4 chains with...
Source: Immunotherapy Weekly (2006-02-08)
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