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Arthritis Pathogenesis
Candida albicans cell wall glucan promotes autoimmune arthritis
February 8th, 2006
A Candida albicans cell wall glucan acts as an adjuvant for induction of autoimmune arthritis in mice. "Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) and has aided research into the pathogenesis of inflammatory joint disease. Typically, Type II collagen (CII) emulsified with Freund's complete adjuvant (FCA) is injected into DBA/I mice. After a booster injection, the mice develop inflammation of the paws. But the fact that the immunization of CII alone does not induce arthritis suggests that activation of the immune system by an adjuvant is necessary for induction of the arthritis," scientists writing in the Journal of...
Source: Immunotherapy Weekly (2006-02-08)
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