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Bordetella Vaccine
Mechanism of clearance of Bordetella from lungs requires TLR4
February 8th, 2006
The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. "Although the antibacterial effects of antibodies are well studied in in vitro systems, the in vivo effects of antibodies cannot always be accurately predicted. Complicated cross-talk between different effector functions of antibodies and various arms of the immune system can affect their activities in vivo. Using the mouse respiratory pathogen Bordetella bronchiseptica, we examined the mechanisms of antibody-mediated clearance of bacteria from the respiratory tract," scientists in the United States report. "Interestingly, although TLR4 was...
Source: Immunotherapy Weekly (2006-02-08)
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