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DNA Research
Skeletal muscle gene expression is enhanced by a polymer excipient Pluronic P85
February 8th, 2006
Recent research from the United States has chronicled the promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85. "Amphiphilic triblock copolymers of ethylene oxide and propylene oxide (Pluronic) significantly enhanced expression of plasmid DNA in the skeletal muscle. In the presence of Pluronic P85 (P85) high levels of expression of a reporter gene (luciferase) were sustained for at least 40 days and the area under the gene expression curve increased by at least 10 times compared to the DNA alone," wrote Z.H. Yang and colleagues, Durham Research Center. "The effect of Pluronic...
Source: Immunotherapy Weekly (2006-02-08)
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