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DNA Vaccine
CD4+ T cell-independent DNA vaccine shows promise against opportunistic infections
February 8th, 2006
CD4+ T cell-independent DNA vaccination shows promise against opportunistic infections. "Depletion or dysfunction of CD4+ T lymphocytes profoundly perturbs host defenses and impairs immunogenicity of vaccines. We show that plasmid DNA vaccination with a cassette encoding antigen (OVA) and a second cassette encoding full-length CD40 ligand (CD40L), a molecule expressed on activated CD4+ T lymphocytes and critical for T cell helper function, can elicit significant titers of antigen-specific immunoglobulins in serum and Tc1 CD8+ T cell responses in CD4-deficient mice," scientists writing in the Journal of Clinical Investigation report. "To...
Source: Immunotherapy Weekly (2006-02-08)
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