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Dengue Vaccine
Recombinant yellow fever 17D-dengue type 2 virus shows promise for dengue fever vaccine
February 8th, 2006
A recombinant yellow fever 17D-dengue type 2 virus shows promise for a dengue fever vaccine. According to recent research from Brazil, "A chimeric yellow fever (YF)-dengue serotype 2 (dengue 2) virus was constructed by replacing the premembrane and envelope genes of the YF 17D virus with those from dengue 2 virus strains of Southeast Asian genotype. The virus grew to high titers in Vero cells and, after passage 2, was used for immunogenicity and attenuation studies in rhesus monkeys. Subcutaneous immunization of naive rhesus monkeys with the 17D-D2 chimeric virus induced a neutralizing antibody response associated with the protection of six of seven monkeys against...
Source: Immunotherapy Weekly (2006-02-08)
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