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Adenocarcinomas
COX-2 is expressed in stromal myofibroblasts surrounding colon adenocarcinomas
February 8th, 2006
Research from Greece has documented that PPAR-gamma is expressed and NF-KB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. "Accumulated evidence indicates that carcinogenesis is closely associated with the transformation of normal stroma into a reactive stromal phenotype," wrote G.P. Vandoros and colleagues, University of Patras. "The present study investigated the role of PPAR gamma, COX-2 and p-IkB-alpha-important molecular targets of colon cancer chemoprevention in this stromal remodeling by evaluating and comparing the expression of these factors in stromal...
Source: Immunotherapy Weekly (2006-02-08)
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