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Immunotherapy Weekly

Susan Hasty, Publisher

Table of Contents . . . April 5th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Immunotherapy Weekly | Other Publications

Allergy & Immunology - Modified Langerhans-type dendritic cells express full-length stimulatory antigen

Allergy & Immunology - Stem cell factor is a potential therapeutic target in asthma

Autoimmune Diseases - New study shows antibody-interleukin complexes stimulate immune responses

Influenza Vaccines - Influenza vaccine supply in U.S. needs strengthening

Acute Myeloid Leukemia - Acute myeloid leukemia risk associated with treatments for Hodgkin lymphoma estimated

Adenovirus Vaccine - Vaccines elicit CD8+T cell immunity under extreme leukopenia

Adverse Drug Reaction - Adverse reactions to permanent eyeliner tattoos have occurred

Allergy & Immunology - Alcohol consumption during pregnancy increases the risk of atopic dermatitis in infants

Allergy & Immunology - Asian ladybug may have potential to cause reaction for allergy suffers

Allergy & Immunology - Phospholipase is critical in macrophage engulfment

Allergy & Immunology - T cell activation is enhanced by mast cells

Apoptosis - Hepatoma cell apoptosis is enhanced by interferon-alpha

Arthritis - Differences in arthritis progression depend on collagen composition

Arthritis - Rheumatoid arthritis can be distinguished from Sjogren syndrome

Arthritis & Cancer - New insights into the link between rheumatoid arthritis and cancer

Asthma - Allegheny physicians report secondhand smoke may trigger childhood asthma and allergy

Asthma - Asthma exacerbations not much lower over time despite treatment options, study shows

Asthma - Racial/ethnic disparities exist in asthma treatment

Atherosclerosis - Atheroprotective effect of adjuvants is seen in apolipoprotein E knockout mice

Autoimmune Diseases - Faulty immune-priming cells start autoimmunity

Autoimmune Diseases - In autoimmune hepatitis, P2X(7) receptors regulate NKT cells

Biotechnology - Diosynth enters long-term commercial supply agreement with Dendreon Corp.

Bladder Cancer - Findings in bladder cancer provide new insights

Bone Marrow - Hepatocyte-bone marrow cell fusion is driven by immune-mediated hepatitis

Breast Cancer - Herceptin sensitizes ErbB2-overexpressing cells to apoptosis

Breast Cancer - Presence of inflammatory response indicated poor outcome in breast cancer patients

Cancer Immunotherapy - Kinase insert domain-containing receptor draws cytotoxic cells to tumor vessels

Cancer Incidence - Frequency of additional cancers in patients with splenic marginal zone lymphoma assessed

Cancer Research - Promising preclinical results from oncolytic virus research using hamster model published

Cancer Therapy - Anaplastic lymphoma kinase activity is essential for lymphoma cells

Cancer Therapy - Hook effect in calcitonin immunoradiometric assays can alter prognosis

Cancer Therapy - Most patients with lymphoma succumb to infectious complications

Cancer Therapy - New findings in cancer therapy described

Cancer Therapy - Trastuzumab breast cancer therapy efficacy predicted by PTEN activity

Cancer Vaccine - Antitumor immunity is enhanced by DNA vaccine encoding chemokines and prostate-tumor antigens

Cancer Vaccine - Antitumor responses are elicited by low dose of live tumor cells

Cancer Vaccine - Cancer vaccine development is aided by data on tumor antigen processing and presentation

Cancer Vaccine - Chemotherapy-p53 cancer vaccine combination induces small cell lung cancer immune response

Cancer Vaccine - Green fluorescent protein-expressing murine tumor cured by photodynamic therapy

Cancer Vaccine - Leukemia vaccination is the focus of review

Cancer Vaccine - Melanoma-associated CTL response is enhanced by CD4 T cells in transgenic mice

Cancer Vaccine - Method to predict structure of peptides bound to MHC class I has been developed

Cancer Vaccine - Monoclonal antibodies to hepatocyte growth factor show therapeutic potential against tumors

Cancer Vaccine - PAX-FKHR fusion protein breakpoint epitope induces CTL that lyse tumors

Cancer Vaccine - Proteasome-inhibited dendritic cells improve HLA-class I peptide epitope presentation

Cancer Vaccine - Telomerase peptides are immunizing agent in cancer patients

Cancer Vaccine - Tumor immunity is enhanced by canary pox virus expressing melanoma antigen

Cancer Vaccine - Tumor vaccine development is using recognition of tumor glycans by antigen-presenting cells

Cancer Vaccines - Data advance knowledge in cancer vaccines research

Cancer Vaccines - New data illuminates research in cancer vaccines

Cancer Vaccines - Recent findings in cancer vaccines provide new insights

Cancer Vaccines - Reports add new data to cancer vaccines research

Cancer Vaccines - Researchers detail new studies and findings in the area of cancer vaccines

Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge

Cardiology - New findings in the area of cardiology described

Cell Biology - Nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands

Chagas Disease - Night blindness is a new clinical symptom of Chagas disease

Chronic Hepatitis C - Chronic hepatitis C therapy is associated with a sustained virological response

Chronic Infections - Chronic hepatitis B is effectively treated by a lamivudine-interferon regimen

Clinical Trials - Boehringer Ingelheim closes one arm of Aptivus (tipranavir) study

Clinical Trials - Genmab reports positive results form HuMax-CD20 rheumatoid arthritis study

Clinical Trials - Novogen IBD drug phase I clinical trial shows promise

Clinical Trials - Phase I/II trial data of Avrina, drug candidate for eczema, presented by Corgentech

Clinical Trials - Positive TOLAMBA phase II/III results presented by Dynavax at AAAAI meeting

Clinical Trials - Single-dose famciclovir tablets accelerate healing time of cold sore outbreaks, data show

Clinical Trials - Stanford University doctors discuss flaw in clinical trial of multiple sclerosis drug

Coccidioidomycosis Vaccines - Mechanisms of protective immunity to coccidioidomycosis elucidated

Coccidioidomycosis Vaccines - Researchers describe findings in coccidioidomycosis vaccines studies

Collaborations - Ace BioSciences, Nordic Vaccine unite to develop vaccines

Complementary & Alternative Medicine - Angiogenesis and tumor growth can be thwarted by licorice root extract

DNA Research - Protein-activation complex interaction underlies lipoprotein regulation

Dermatology - Atopic dermatitis-like model in mice determines parasitism of mites, not allergies, are the cause

Dermatomyositis - Oral lesions identified as initial manifestation of dermatomyositis with occult malignancy

Diabetes Pathogenesis - Defective CTLA-4 induction is controlled by gene(s) in Idd5.1 region in nonobese diabetics

Diabetes Pathogenesis - High macrophage migration inhibitory factor levels precede type 2 diabetes onset

Diabetes Pathogenesis - New research in the area of diabetes pathogenesis detailed

Diagnostics - Signet, Bayer sign agreement to do research on urinary trypsin inhibitor immunoassays

Diagnostics - Smallpox identification crucial for early detection and response

Diagnostics - West Nile Virus may cause infectious cerebrospinal fluid pleocytosis

Drug Development - Allergy Therapeutics completes Pollinex Quattro phase II grass program

Drug Development - Altana submits new drug application to U.S. FDA for Ciclesonide nasal spray

Drug Development - Atherogenic inflammation may be target for therapeutic development of mycophenolate mofetil

Drug Development - Avidex completes two phase I studies for RhuDex

Drug Development - BioMS Medical's MBP8298 shows 5-year delay of multiple sclerosis disease progression

Drug Development - Rotavirus vaccine development is aided by cytokine response analysis

Drug Toxicity - Drug toxicity may be higher in neonates and young children due to an underdeveloped P-glycoprotein

Electronic Medical Records - Immunization registries are aided by electronic medical records

Epidemiology - Enteric disease risk and vaccination attitudes differs among rural Chinese

Epidemiology - SIV prevalence rates vary widely among naturally infected primate species from Cameroon

Finance - EntreMed reports fourth quarter and year-end 2005 financial results

Finance - Favrille announces $45 million financing to support FavId development

Finance - GTC Biotherapeutics reports fourth quarter, year-end 2005 financial results down

Finance - Galapagos announces revenue, net loss increases in 2005

Finance - Immune Response Corporation completes $8 million private financing

Finance - PhotoMedex announces fourth quarter revenues up 56% to $7,722,166

Food Allergies - FAAN discusses risk-taking and coping strategies of teens with food allergies

Gene Research - Liver-specific lentiviral vector successfully treats UGT1A1 deficiency

Gene Research - Polymer-coated chick embryo lethal orphan virus can target mammalian cells

Generic Drugs - Par Pharmaceutical resumes shipment of generic Flonase

Genetics & Genomics - Gene expression profiling identifies molecular classifiers of ovarian cancer

HIV/AIDS & Hepatitis - Liver fibrosis is predicted in HIV/hepatitis C coinfections

HIV/AIDS & Syphilis - Syphilis is a problem in migrant and urban populations in eastern China

HIV/AIDS Drug Resistance - Researchers report details of new studies and findings in the area of HIV/AIDS drug resistance

HIV/AIDS Epidemiology - HIV-1 non-B subtype transmission continues in the U.K.

HIV/AIDS Genetics & Genomics - HIV disease progression rate influenced by HLA-B locus polymorphism

HIV/AIDS HAART - ABC, 3TC, and ZDV is reasonable for HAART-naive patients when other regimens are ill-advised

HIV/AIDS HAART - HAART initiation and continuation hinders HIV 103N and 184V mutations alone or in tandem

HIV/AIDS HAART - HIV-1 RNA helps guide patient selection for HAART in resource-poor settings

HIV/AIDS HAART - New data illuminates research in HIV/AIDS HAART

HIV/AIDS HAART - Recent findings illuminate research in HIV/AIDS HAART

HIV/AIDS Pathogenesis - HIV RNA upregulation in latently infected cells occurs within 2 hours after stimulation

HIV/AIDS Pathogenesis - HIV Vpr uses the glucocorticoid receptor pathway as a recruitment vehicle for PARP-1

HIV/AIDS Pathogenesis - HIV infection in astrocytes altered by cytokine priming

HIV/AIDS Pathogenesis - HIV-1 R5 variants preferentially infect CD62L- CD4+ cells and are potentially NRTI-resistant

HIV/AIDS Pathogenesis - HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ cells

HIV/AIDS Pathogenesis - Studies advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Prognosis - IL6/MHC gene mutations related to CD4 recovery in patients with stable virologic response

HIV/AIDS Prognostics - Increased serum immunoglobulin G levels associated with ethnicity in HIV/AIDS

HIV/AIDS Risk Factors - HSV-2 infection is the important risk factor for HIV infection in Tanzania

HIV/AIDS Seroreversion - HIV antibody seroreversion does not indicate viral eradication

HIV/AIDS Vaccine -  Mycobacterium smegmatis vaccine vector expressing HIV Env generates CD8+ T cell responses

HIV/AIDS Vaccine - CD40 and GITR ligands act as adjuvants for HIV DNA vaccines

HIV/AIDS Vaccine - HIV-1 vaccines were safe in healthy HIV-1-uninfected volunteers

HIV/AIDS Vaccine - HIV-infected cells are selectively eliminated by HIV-based virus-like particles

HIV/AIDS Vaccines - New research in the area of HIV/AIDS vaccines detailed

HIV/AIDS Vaccines - Researchers' findings advance HIV/AIDS vaccines research

HIV/AIDS Vertical Transmission - HIV-1 neutralization escape variants are transmitted from mother to infant

HIV/AIDS-Associated Dementia - AIDS-associated neuronal loss may be due to neuronal apoptosis

HIV/AIDS-Associated Kaposi Sarcoma - Interferon-alpha 2b dose safety established in HAART-treated AIDS-associated KS patients

Head & Neck Cancer - U.S. FDA approves ERBITUX (Cetuximab) for treatment of head and neck cancer

Hepatitis B Virus - Chronic HBV infection produces antigens and DNA in ovary and ovum

Hepatitis B Virus - HBV replication is blocked by asialoglycoprotein receptor antisense oligonucleotides

Hepatitis B Virus - HBV surface antigen T and B cell memory triggers B cell antibody production

Hepatitis B Virus - HBV surface antigen used to generate high-affinity chimeric antibody

Hepatitis B Virus - Hepatitis B recurrence after liver transplantation is preventable

Hepatitis B Virus - Patients with hepatitis B have a poor response to lamivudine monotherapy

Hepatitis B Virus - Recent findings illuminate research in hepatitis B virus

Hepatitis C Vaccine - T cell hepatitis C vaccine effective against virus challenge

Hepatitis C Virus - Anti-hepatitis C virus responses activated by a toll-like receptor

Hepatitis C Virus - HCV immune-complex dynamics predict response to therapy

Hepatitis C Virus - HCV indeterminate group correlates with antibody assay results

Hepatitis C Virus - Hepatitis C-related type II mixed cryoglobulinemia involves E2-IgM complex

Hepatitis C Virus - Important hepatitis C virus NS4A epitope identified by phage display

Hepatitis C Virus - Novel HCV vector overcomes anti-Ad5 immunity and induces immune responses

Hepatitis C Virus - Studies add new findings to hepatitis C virus body of knowledge

Hepatitis Delta Virus - ADAR 1 enhances hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells

Hepatocellular Carcinoma - Hepatocellular carcinoma development is associated with serum proteome changes

Herpes Simplex Virus - Herpes simplex virus pathogenesis involves dual role of keratin

Hookworm Vaccine -  Ancylostoma caninum larvae vaccine induces Th2 protective response

Human Papillomavirus - HPV-16 fusion protein vaccine possesses therapeutic effects in animal model

Human Papillomavirus Vaccines - New findings in the area of human papillomavirus vaccines detailed

Immunology - New anaphylaxis research shows the need for additional education, research

Immunotherapy - Anti-TNF antibody neutralizing activity has been characterized

Immunotherapy - Dendritic cells provide link between innate and adaptive immunity

Immunotherapy - GM-CSF genetic adjuvant promotes prophylactic DNA vaccination against pseudorabies

Immunotherapy - Immunologic memory response was induced by meningococcal vaccine using P64k protein carrier

Immunotherapy - Immunostimulant platform very active against PTV infection in mouse model, research shows

Immunotherapy - Intracellular trafficking of plasmids during transfection mediated by microtubules

Immunotherapy - Methods to quantify antigen-specific T cell clones in mycobacterial infection developed

Immunotherapy - Monoclonal antibodies generated to native mouse angiotensin-converting enzyme

Immunotherapy - Myasthenia gravis is alleviated by peptide vaccine in alum and inactive pertussis

Immunotherapy - Toxin-mediated antigen delivery into dendritic cells elicits CD8+ T cells

Influenza Vaccine - Influenza vaccination is prompted by worry and regret

Influenza Vaccine - Recombinant influenza A viruses induce heterospecific B and T cell responses

Influenza Vaccine - Vaccination coverage in U.S. is affected by ethnicity

Influenza Vaccines - Influenza virus study demonstrates uneven distribution of MHC class II epitopes

Leishmaniasis Research -  Leishmania uptake by dendritic cells promotes protective immunity

Leukemia Vaccine - High-risk leukemia immunotherapy is provided by autologous vaccine expressing CD40L and IL-2

Liver Diseases - Chronic inflammatory liver diseases involve the expression of epithelial cellular adhesion molecule

Lung Cancer - Lung cancer prognosticated by infiltration by CD8+ T cells and CD4+ T cells

Lung Cancer - Recent findings illuminate research in lung cancer

Lung Cancer Research - Some chemically modified heparins may deserve further testing as NSCLC treatment protocols

Lymphoma - HA14-1 induced apoptosis in follicular lymphoma B cells

Market Analysis - Market study analyzes potential launches, R&D pipelines of players in asthma, COPD area

Measles Vaccine - Aerosol measles vaccine is effective primary vaccine in nine-month-old children

Measles Vaccine - IgG ELISAs are accurate for identifying people needing measles vaccination

Melanoma Vaccine - Metastatic melanoma responses are induced by dendritoma vaccine plus IL-2

Meningococcal Vaccine - Cost-effectiveness of meningococcal serogroup C conjugate vaccines is reassessed

Mergers & Acquisitions - Inverness Medical Innovations agrees to acquire ACON Lab's rapid diagnostics business

Mergers & Acquisitions - Inverness acquires chip technology for nucleic acid, immunoassay-based diagnostics

Metapneumovirus Vaccine - Metapneumovirus is protected against by cytotoxic T-lymphocyte epitope vaccine

Multiple Myeloma Therapy - U.S. FDA grants priority review for treatment of relapsed or refractory multiple myeloma

Multiple Sclerosis - HLA typing of MS patients may help identify patients for alternative therapies

Neurogenesis - Neurogenesis occurs in neuroinflammatory lesions in the adult spinal cord

Non-Hodgkin Lymphoma - Detection of bone marrow lesions improved by ferumoxtran-10-enhanced MR imaging

Obesity Epidemic - Poll finds obesity epidemic continues to worsen in the United States

Oncology - Breast cancer and lymph system angiogenesis correlate with patient prognosis

Osteoarthritis - Meniscus plays a critical role in osteoarthritis of the knee

Ovarian Cancer - B7-H4 appears to be a promising new biomarker for ovarian cancer

Ovarian Cancer Vaccine - Humoral immune responses are induced by anti-idiotypic antibody fusion protein

Parasitology -  Schistosoma japonicum plasmid DNA vaccine protects against infection

Parasitology - Immunity to intestinal nematodes is enhanced by IL-9-producing dendritic cells

Parasitology - Transmission of Plasmodium from mosquito to mammal has newly identified step

Pediatric Vaccine - Pediatric vaccine stockpile program in U.S. is described

Pediatric Vaccines - U.S. CDC perspective on vaccine supply problems is presented

Personnel - CytoDyn names Dr. Trevor Hawkins to its scientific advisory board

Personnel - Dendreon names Ernest Bognar general manager of Hanover manufacturing facility

Pharmaceutical Research - Fenofibrate plus candesartan improves endothelial function and reduces inflammatory markers

Pharmaceutical Research - Phase III drugs slated to add additional $30 billion in revenues by 2010

Pneumococcal Vaccine - Pneumococcal vaccine shortage prevention strategies are presented

Pneumococcal Vaccines - Findings describe new data in pneumococcal vaccines research

Prostate Cancer - Prostate tumor development inhibited in a transgenic adenocarcinoma model

Prostate Cancer Vaccine - Pox prostate specific antigen-targeted therapeutic vaccines were safe and immunogenic

Prostate Cancer Vaccine - Prostate cancer vaccine's immune response is enhanced by intradermal electroporation

Proteomics - Bone marrow B lymphopoiesis inhibited by bone morphogenic protein-6

Proteomics - Interferon-alpha mediates anti-HIV activity via APOBEC3G induction

Proteomics - Method generates monoclonal antibodies against plasma proteins

Pseudomonas Vaccine - Oral whole-cell Pseudomonas aeruginosa vaccine safe and immunogenic

Psoriasis - "Encouraging" CC-10004 data, as new oral therapy in severe psoriasis presented by Celgene

Public Health - Adult willingness to be vaccinated against shigella varies throughout Asia

Public Health - Influenza vaccination reduces illness in 2- to 5-year-old children

Public Health - Influenza vaccine refusal reasons among high-risk persons in Europe are reported

Public Health - Public health practice is affected by anecdotal evidence

Public Health - Vaccine supply strengthening in U.S. is focus of review

Rabies Vaccine - Rabies protection in dogs is delivered by one-time DNA vaccine

Respiratory Medicine - Advances in asthma research presented at meeting

Respiratory Medicine - Cancer radiotherapy receives a boost from all-trans retinoic acid

Respiratory Medicine - Nearly half of asthma-related ED visits made by intermittent asthma patients, study shows

SARS Vaccines - SARS coronavirus vaccine has been developed

Seasonal Allergic Rhinitis - Positive Ciclesonide data presented at AAAAI by Sylvana Research

Septicemia Vaccine - CpG oligodinucleotides induce strong responses to streptococcic septicemia vaccine

Smallpox Vaccines - Vaccinia and smallpox viruses were neutralized by monoclonal antibodies

Streptococcal Vaccine -  Streptococcus pneumoniae resists DNA vaccines based on pneumolysin

T Cells - T cell activation requires HuR nuclear export and cytokine mRNA stabilization

Tissue Engineering - Combined strategy reduces restenosis for vascular tissue engineering applications

Tissue Engineering - Enzo receives approval to begin HIV clinical trial

Tissue Engineering - Tissue-engineered cartilage and osteochondral plug treats osteoarthritis of knee

Transplant Medicine - Researchers' work adds to transplant medicine body of knowledge

Transplant Medicine - Studies advance knowledge in transplant medicine research

Transplantation Biology - Acute hepatitis in renal pretransplantation significantly increases risk

Transplantation Biology - Liver transplantation outcome is aided by hepatitis B immunization

Transplantation Biology - Post-liver transplantation rejection is indicated by C4d

Tuberculosis Vaccines - BCG vaccine protection is impaired in IL-15-deficient mice

Tuberculosis Vaccines - Findings describe new data in tuberculosis vaccines research

Tumor Suppression - Tumor rejection by T cells involves NK-cell activation

Type 1 Diabetes - Human leukocyte antigen haplotypes may trigger pregnancy-related fulminant type 1 diabetes

Vaccine Delivery - DNA vaccine is targeted to skin with the use of electroporation

Vaccine Efficacy - Pneumococcal vaccination during pregnancy does not prevent infant infection

Vaccine Safety - Sudden infant death syndrome case is linked to hexavalent vaccine

Vaccine Safety - Vaccine liability update is presented

Vaccines Adjuvant - New findings in vaccines adjuvant described

Vaccines Delivery - New findings in the area of vaccines delivery detailed

Virology - Adenovirus vectors sustain inducible transgene expression in brain

Virology - HTLV-2b replication higher in endemically versus epidemically acquired infections

Virology - Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious pathology

Virology - Vaccinia virus lacking core proteins accumulates on endoplasmic reticulum structures

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