Cancer Vaccine

Melanoma-associated CTL response is enhanced by CD4 T cells in transgenic mice

Published in Immunotherapy Weekly, April 5th, 2006

Investigators have identified the CD4-dependent potentiation of a high molecular weight-melanoma-associated antigen-specific CTL response in HLA-A2/K^b transgenic mice.

"The human high molecular weight (m.w.)-melanoma-associated antigen (HMW-MAA) is ail attractive target for the immunotherapy of melanoma, due to its relatively high expression in a high percentage of melanoma lesions and its restricted distribution in normal tissues. Active immunization with HMW-MAA mimics has been previously shown to induce a HMW-MAA-specific, T cell-dependent Ab response associated with an apparent clinically beneficial effect in advanced melanoma patients," researchers in...

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Source: Immunotherapy Weekly (2006-04-05)

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