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Proteomics

Autocrine class 3 semaphorin system regulates podocyte survival

Published in Immunotherapy Weekly, June 28th, 2006

According to a study from the United States, autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival.

"Class 3 semaphorins are guidance proteins that play crucial roles during development. Semaphorins 3A (sema 3A) and 3F are expressed by podocytes in vivo throughout ontogeny and their function is unknown.

"Here we examined the expression of class 3 semaphorins (3A, 3B, 3C, 3D, 3E, and 3F) and their receptors (neuropilins 1 and 2, plexins A1, A2, A3, B2, and D1) in undifferentiated and differentiated mouse podocytes using reverse transcriptase-polymerase chain reaction (RT-PCR)," wrote F. Guan and colleagues,...

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