Published in Immunotherapy Weekly, July 26th, 2006
According to a study from Brazil, "Experimental allergic encephatomyetitis (EAE) is a neuro-inflammatory, autoimmune disorder in which myetin-reactive Th1 T cells with a restricted TCRV beta repertoire play a pathogenic role. Here, I show that an engineered single-chain T-cell receptor (TCR) containing dominant TCRV alpha/V beta encephalitogenic elements, when administered in aluminum adjuvant, generates a marked anti-TCR humoral response that correlated with protection against the development of EAE in V beta 8-expressing B10.PL but not in V beta 8-deficient SJL...
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