Immunotherapy Weekly

Allergy & Immunology - Researchers make progress in the battle against anaphylactic shock

Asthma - Montelukast improves pulmonary function measured by impulse oscillometry

HIV/AIDS Research - Viral Genetics' study of protein-based therapy for treating AIDS yields significant results

Immunotherapy - Immune responses specifically inhibited in vivo by c-MIR

Respiratory Medicine - Roflumilast shows promise for asthma and COPD treatment

Allergy & Immunology - Aspergillus-sensitized early airway response inhibited by a surfactant protein

Allergy & Immunology - CC chemokine receptor antagonists selectively inhibit eosinophil influx into lungs

Allergy & Immunology - Non-Invasive Monitoring Systems announces effectiveness of therapeutic vibrator device in asthma

Allergy & Immunology - Rhinitis intranasal treatment submitted for U.S. and European marketing approval

Antibacterial Agents - Lysozyme-mediated peptidoglycan degradation is not required for bactericidal activity

Asthma - Age, gender comparison in children with RSV infection may inform asthma pathogenesis

Asthma - Critical Therapeutics completes clinical trial of intravenous zileuton in patients with asthma

Asthma - Polymorphism is associated with a susceptibility to aspirin-intolerant asthma

Atherosclerosis - Human oxidized low-density lipoprotein markers may be associated with chronic infections

Autoimmune Disease - Antibodies to polysaccharides protect against severe infection in C2 deficiency

Avian Influenza - Bird flu virus NS1 gene was progressively truncated after circulation in poultry

Bacteriology - Variation in glucose homeostasis and insulin action linked to bacterial environment

Behavioral Medicine - Lower cognitive social maturity and greater life change events predicts adolescent risk behaviors

Behcet Disease - Morphologic evidence of subclinical atherosclerosis was obtained in Behcet's disease patients

Bone Marrow - Tumor growth impeded natural-killer-cell maturation

Business & Finance - Dynavax reports net loss of $15.3 million in second quarter

Business & Finance - Hemispherx wins AMEX compliance approval, looks ahead to promising pharmaceutical lineup

Business Update - Tandem Labs to offer BioVeris products for analytical services

Cancer Gene Therapy - Adenovirus-mediated delivery of genes elicits potent antitumor effect

Cancer Gene Therapy - Antitumor efficacy enhanced by interleukin monoclonal antibody

Cancer Gene Therapy - Elimination and methylation of integrated cDNA occurs differently

Cancer Gene Therapy - T cell receptor transduced into primary human lymphocytes

Cancer Therapy - PD-L1/PD-1 interactions negatively regulate T cell effector functions

Cancer Vaccine - Activity of CD20 monoclonal antibodies is linked to unique CD20 epitopes

Cancer Vaccine - Modified tyrosinase-related protein epitope is not efficacious in tumor model

Cancer Vaccine - N-terminal GRP94 fragment is sufficient for peptide presentation via antigen-presenting cells

Cancer Vaccine - Secondary immunization delays advanced-stage tumor progression

Candida Albicans Epidemiology -  Candida albicans strains characterized by multilocus sequence typing

Cardiology - Post-cardiac surgery interferon suppression is caused by decreased interleukin

Cardiovascular Research - Gout increases risk of heart attack

Cell Therapy - Functional thymus formation initiated by postnatal epithelial progenitor cell

Central Nervous System - Case of primary extranodal nasal-type natural killer/T cell lymphoma of the brain reported

Cervical Cancer - Cervical carcinoma prognosticated by lymphatic vessel density

Cholangiocarcinoma - Trp inhibitor may mark the early recurrence of intrahepatic cholangiocarcinoma

Coronavirus Diagnostics - All coronavirus infections diagnosed by multiple primer sets targeting different genes

DNA Vaccine - Plasmid size up to 20 kbp does not limit lung gene transfer using DNA nanoparticles

Dengue Vaccine - Dengue 2 virus nonstructural glycoprotein NS1 was expressed in Pichia pastoris

Diabetes & Heart Disease - Stress-induced cytokines secretion raises insulin resistance-related complications

Diabetes Complications - Dysregulated Toll-like receptor signaling affects macrophage-mediated diabetes complications

Diabetes Pathogenesis - Tolerance to proinsulin-2 is due to radio-resistant thymic cells

Diagnostics - Nephrogenic adenoma differentiated from prostatic carcinoma by antigen markers

Encephalitis - Virus-specific CD4 T cells are pathogenic in acute encephalitis

Endocrinology - Coactivator-associated arginine methyltransferase-1 enhances NF-kappa B-mediated gene transcription

Finance - Seattle Genetics reports Q2 2006 revenues of $2.8 million up, from $2.2 million in Q2 2005

Finance - Sepracor reports Q2 2006 consolidated revenues of $264.4 million

Gastroenterology - Memory CD4+ T cell subsets persist after helminth infection to protect against challenge

Gestational Asthma - T-helper 1/2 chemokine imbalance may predict women at risk for severe gestational asthma

Glioma Vaccine - Dendritic cells pulsed with glioma lysates increase survival of tumor-bearing mice

HIV/AIDS & Mycoplasma Pneumoniae -  Mycoplasma pneumoniae seroprevalence determined in HIV-infected patients in Chennai

HIV/AIDS Behavioral Medicine - Spontaneous cognition is an independent predictor of HIV risk behavior tendencies

HIV/AIDS Chronic Diarrhea - Moderate lactose ingestion does not worsen diarrhea in HIV-infected persons

HIV/AIDS Drug Development - HIV-1 replication suppressed by arginine deiminase of Mycoplasma arginini

HIV/AIDS Epidemiology - HLA-B58s alleles have an impact on HIV-1 infection among native Africans

HIV/AIDS HAART - Hierarchical Bayesian method estimates long-term HIV dynamics with HAART

HIV/AIDS Impact - Demographic impact of AIDS and number of people in need of treatment projected

HIV/AIDS Long-Term Nonprogressors - Anti-CCR5 antibody induction may protect against HIV progression in long-term nonprogressors

HIV/AIDS Oral Candidiasis - CD8+ T cells in oral lesions of HIV patients are normal activated T cells

HIV/AIDS Pathogenesis - Cumulative mutations of ubiquitin acceptor sites in HIV-1 Gag cause late budding defect

HIV/AIDS Pathogenesis - HIV ability to completely evade neutralizing antibody responses is limited

HIV/AIDS Pathogenesis - HIV protease cleaves poly(A)-binding protein

HIV/AIDS Pathogenesis - HIV-1 Nef adapts to intracellular trafficking pathways

HIV/AIDS Pathogenesis - HIV-1 transcriptional promoter DNA-binding sites evolve under strong selection

HIV/AIDS Pathogenesis - Nonmacrophage-tropic HIV-1 R5 envelopes predominate in blood, lymph nodes and semen

HIV/AIDS Perinatal Transmission - Maternal autologous neutralizing antibody protective against perinatal HIV-1 transmission

HIV/AIDS Progression - SIV Tat evolution correlates with AIDS progression during morphine-dependence

HIV/AIDS Replication - Statistical method compares HIV growth curves

HIV/AIDS Risk Factors - HIV-infected injection drug-using women engage in risky sex with HIV-uninfected men

HIV/AIDS Stigma - HIV and AIDS stigma violates human rights in five African countries

HIV/AIDS Treatment - Hydroxyurea not beneficial as part of structured treatment interruptions in primary HIV infection

HIV/AIDS Vaccine - Cleaved, trimeric HIV-1 envelope glycoprotein vaccine antigens have been produced

HIV/AIDS Vaccine - Hematopoietic stem cells provide protection against HIV infection

HIV/AIDS Vaccine - HIV-neutralizing monoclonal antibody 4E10 recognizes N-terminal sequences on native antigen

HIV/AIDS Vaccine - IL-21 and IL-15 gene delivery enhances immunity induced by DNA vaccine expressing HIV glycoprotein

HIV/AIDS Vaccine - Locally elicited immune responses at mucosal entry sites likely to favor immune activation

HIV/AIDS Vaccine - Relative neutralization sensitivity/resistance is HIV-1 type B isolate reproducible property

HIV/AIDS Vaccine Trials - Sensitivity analyses in HIV vaccine trial compares outcomes only existing in patient subsets

Hemophilia Therapy - Adeno-associated virus delivering factor VIII provides multiyear benefit in hemophilia A

Hepatic Steatosis - Hepatic steatosis is associated with a hepatitis C virus genotype in HIV-seropositive patients

Hepatitis B Virus - China immunizes millions of children against hepatitis B in historic collaboration

Hepatitis B Virus - Genotype distribution determined in chronic hepatitis B virus infections

Hepatitis B Virus - Regulatory T cells influence hepatitis B disease progression

Hepatitis C Virus - HIV co-infection contributes to hepatitis C virus-related fibrosis severity

Hepatitis C Virus - Human sinusoidal endothelium can capture hepatitis C virus particles

Hepatitis C Virus - Specific populations of memory cells display distinct homing phenotypes

Hodgkin Lymphoma - Hodgkin lymphoma patients did not benefit more from radiotherapy than consolidation chemotherapy

Human Papillomavirus - Human papillomavirus DNA detection enhanced by linear array HPV genotype assay

Immunotherapy - B cells and dendritic cells from transgenic mice activate T cells

Immunotherapy - Valency contributes to detection and sorting of antigen-specific T cells

Infectious Diseases -  Haemophilus influenzae surface fibrils contribute to serum resistance

Infectious Diseases - Viral amino acid envelope mutations closely correlate with pathogenicity

Inflammatory Bowel Disease - Human and murine RegIII proteins expressed in E. coli were characterized

Influenza - MedImmune begins shipping live intranasal flu vaccine for 2006-2007 after U.S. FDA release

Influenza Vaccine - Computer model addresses pandemic influenza in 21st century

Influenza Vaccine - Lessons learned from the 2001-2004 Maryland influenza prevention seasons are presented

Influenza Vaccine - Vaccine redistribution model was developed to prevent influenza vaccine shortage

Kidney Transplant Medicine - Large transplant study shows CellCept based drug combination is best immunosuppressant

Leukemia - Adult T cell leukemia apoptosis induced by survivin overexpression and sodium arsenite

Leukemia - Calcineurin-dependent IL-2 production inhibits CD4+CD25+ regulatory T cell function

Leukemia - TAL1 oncoprotein modulates NF-kB1 expression in a subset of human T cell leukemia cells

Licensing Agreements - Sirion Therapeutics acquires U.S. license to develop cyclosporine A ophthalmic compound

Liver Transplantation - Phase III Study shows Prograf as effective as Neoral in kidney transplant recipients

Lung Cancer Vaccine - GM-CSF-producing vaccine after docetaxel improves survival of mice with Lewis lung carcinoma

Lymphoma - Aberrant somatic hypermutation linked to pathogenesis of two lymphoma types

Lymphoma - Indolent differentiated from aggressive lymphoma by CD71 expression

Lymphoma - Primary spinal epidural lymphoma responded better to combined modality treatment than radiotherapy alone

MALT Lymphoma - MALT lymphoma-associated translocations not linked to nuclear BCL-10 expression

Melanoma Vaccine - Allogeneic cell vaccine shows promise against melanoma in phase 1 trial

Melanoma Vaccine - CpG-ODN enhances immune effects of dendritic cell vaccine in melanoma

Mononucleosis Risk Factors - Infectious mononucleosis vaccine may need only to reduce viral load

Neuroscience - Transcription factor functions critically in Purkinje neuron migration

Oncology - Tumor escape mutants develop in immune-privileged environment without T cell selection

Pancreatic Cancer - Increased prevalence of regulatory T cells is induced by pancreas adenocarcinoma

Patents - U.S. patent granted to protect 4SC's DHODH inhibitors and their use as medication

Pediatric Vaccine - Financial sustainability planning for immunization in Cambodia is discussed

Pediatric Vaccine - Parental literacy and religion influence immunization status of children in India

Pediatrics HIV/AIDS Drug Adherence - HAART adherence improved among children switching to once daily lamivudine and abacavir

Pneumococcal Vaccine - State vaccine financing policies affect uptake of pneumococcal conjugate vaccine

Prostate Cancer Vaccine - Provenge plus bevacizumab elicits immune response in prostate cancer

Proteomics - Estrogen receptor acetylation enhances receptor DNA binding

Proteomics - Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses

Proteomics - Improved methods to purify mammalian proteins with poor E. coli expression have been developed

Proteomics - Mouse neural stem cells that stably express human nerve growth factor are characterized

Proteomics - p53 downregulates its activating vaccinia-related kinase 1

Proteomics - Regulatory motif polymorphism alters bone morphogenetic protein RNA

Psoriasis - Psoriatic cells stop emitting vascular endothelial growth factor when treated with spa water

Psoriatic Arthritis - Remicade receives approval as monotherapy for treatment of psoriatic arthritis

Pulmonary Medicine - SOCS3 overexpression enhances IgG immune complex-induced lung injury

Respiratory Medicine - UCB submits application to U.S. FDA for prescription antihistamine to treat allergy symptoms

Retrovirus Pathogenesis - Phosphorylation of HTLV-1 L-domain proteins regulates viral budding

Sepsis Research - Patient unresponsiveness in sepsis may involve blocked transcription

Sepsis Therapy - Liposome-mediated IL-10 gene transfer increases survival in sepsis model