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Hepatocellular Carcinoma

Hepatocellular cancer progression linked to increase of CD4+ CD25+ regulatory T cells

Published in Immunotherapy Weekly, October 11th, 2006

Hepatocellular cancer (HCC) progression could be linked to an increase of CD4+ CD25+ regulatory T-cells.

"The immune response to tumor-specific antigens is typically unable to control the growth and spread of malignant cells. Accumulating evidence indicates that the suppressive effects of CD4+ CD25+ regulatory T-cells are at least partially responsible for the failure of immune-mediated elimination of tumor cells. We have studied 25 patients with HCC," scientists in Japan reported.

"The liver tissues with HCC were separated into the marginal region of tumor (peri-tumor region) and the non-tumor region distant from the tumor," explained X.H. Yang and...

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