Published in Immunotherapy Weekly, October 11th, 2006
"Uracil is present in small amounts in DNA due to spontaneous deamination of cytosine and incorporation of dUMP during replication. While deamination generates mutagenic U:G mismatches, incorporated dUMP results in U:A pairs that are not directly mutagenic, but may be cytotoxic. In most cells, mutations resulting from uracil in DNA are prevented by error-free base excision repair," investigators in Norway reported.
"However, in B-cells uracil in DNA is also a physiological intermediate in acquired immunity," explained L. Hagen and colleagues, Norwegian University Science &...
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