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Anesthesia

Sevoflurane effects on cytokines in patients undergoing CABG are investigated

Published in Immunotherapy Weekly, October 11th, 2006

Sevoflurane suppresses the production of IL-6 and IL-8 cytokines, but not IL-10 and IL-1ra in patients undergoing coronary artery bypass surgery.

According to a study from Japan, "The effects of sevoflurane on proinflammatory cytokines related to ischemic-reperfusion injury are not clear. The hypothesis was tested that sevoflurane decreases myocardial ischemic-reperfusion injury by suppressing proinflammatory cytokines. This was a prospective, randomized study conducted at a medical university heart center."

T. Kawamura and colleagues, Sendai Medical Center, explained, "Twenty-three patients undergoing coronary artery by-pass surgery were allocated...

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