Biotechnology
Protein activity in bacterial inclusion bodies is linked to aggregation rates
Published in Immunotherapy Weekly, October 11th, 2006
According to recent research from Spain, "Recent data show that protein aggregation as bacterial inclusion bodies does not necessarily imply loss of biological activity. We investigated the effect of a large set of single-point mutants of an aggregation-prone protein on its specific activity once deposited in inclusion bodies."
"The activity of such aggregates significantly correlates with the predicted aggregation rates for each mutant, suggesting that rationally tuning the kinetic competition between folding and aggregation might result in highly active...
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Source: Immunotherapy Weekly (2006-10-11)
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