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Cancer Research

Cancer-killing viruses employ multiple mechanisms

Published in Immunotherapy Weekly, October 11th, 2006

The search for safe, effective cancer therapies has led numerous academic and industrial research groups to investigate oncolytic, or cancer-killing viruses.

Oncolytic viruses, which include the naturally occurring reovirus, infect cancer cells while sparing healthy tissues. Once inside the tumor cell, the viruses produce thousands of copies of themselves, causing tumor cells to burst. After tumor cells die, viruses clear rapidly from the body without harming the patient.

More recently, however, it has been discovered that the reovirus may also have the potential to prime the body's own immune system to mount a defense against cancer cells....

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