Cancer Therapy
Mitochondria are therapeutic targets for cancer chemotherapy
Published in Immunotherapy Weekly, October 11th, 2006
According to a report from France, "Mitochondria are vital for cellular bioenergetics and play a central role in determining the point-of-no-return of the apoptotic process. As a consequence, mitochondria exert a dual function in carcinogenesis. Cancer-associated changes in cellular metabolism (the Warburg effect) influence mitochondrial function, and the invalidation of apoptosis is linked to an inhibition of mitochondrial outer membrane permeabilization (MOMP)."
"On theoretical grounds, it is tempting to develop specific therapeutic interventions that target the mitochondrial Achilles'...
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Source: Immunotherapy Weekly (2006-10-11)
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