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Autoimmune Disease Cell Biology
Studies from University of Connecticut, Department of Immunology update current data on autoimmune disease cell biology
April 11th, 2007
Fresh data on autoimmune disease are presented in the report "Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96. Proinflammatory cytokine IL-23 but not IL-12 is critical for the pathogenesis of organ-specific autoimmune diseases including experimental autoimmune encephalitis and collagen-induced arthritis. The contribution by IL-23 in systemic autoimmune diseases such as lupus is undefined," scientists in the United States report. "We addressed this question in a murine lupus-like disease model, initiated by enforced cell-surface expression of an ER HSP gp96 in C57BL/6 background. We...
Source: Immunotherapy Weekly (2007-04-11)
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