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Autoimmune Disease Genetics

Findings in autoimmune disease genetics reported from University of Washington, Department of Immunology

Published in Immunotherapy Weekly, April 18th, 2007

New research, "Lack of Foxp3 function and expression in the thymic epithelium," is the subject of a report. According to recent research from the United States, "Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4(+) T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions."

"Recently, it has been proposed that in addition to T reg cells, Foxp3 is also expressed in thymic epithelial cells where it is involved in regulation of early thymocyte differentiation and is required to prevent autoimmunity. Here,...

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