Immunology

Research in the area of immunology reported from N. Pumphrey and colleagues

Published in Immunotherapy Weekly, October 24th, 2007

A report, 'Cutting edge: Evidence of direct TCR alpha-chain interaction with superantigen,' is newly published data in The Journal of Immunology. "'Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the beta-chain of the TCR," investigators in the United Kingdom report.

"In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable alpha-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g.,...

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Source: Immunotherapy Weekly (2007-10-24)

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