Angiogenesis

Data on angiogenesis published by H.M.W. Verheu and colleagues

Published in Immunotherapy Weekly, December 5th, 2007

According to a study from Netherlands, "One of the key factors that promotes angiogenesis is vascular endothelial growth factor (VEGF). Platelets are the main source of VEGF in blood and contribute to angiogenesis by release of growth factors, including VEGF, from their at-granules on activation."

"The monoclonal antibody bevacizumab blocks VEGF in the blood of patients within hours after administration. Platelets are known to endocytose plasma proteins including immunoglobulins. We tested the hypothesis that platelets take up bevacizumab Fluorescence-activated cell sorting analysis, immunofluorescence imaging, and Western blotting were used to study uptake and release...

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Source: Immunotherapy Weekly (2007-12-05)

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