Angiogenesis
Research Uncovers Molecular Function of Endosialin Target of MORAb-004, Anti-Angiogenic Antibody Being Evaluated for Cancer, Neovascular Disease
Published in Immunotherapy Weekly, December 5th, 2007
Morphotek, Inc. announced that a scientific paper published in the recent issue of The Proceedings of the National Academy of Sciences, sheds new light on the biological role of endosialin, also called TEM1, in promoting angiogenesis and tumor growth. Endosialin/TEM1 is a target of one of Morphotek's therapeutic antibody programs. The article, titled "Interaction of Endosialin/TEM1 with Extra-cellular Matrix Proteins Mediates Adhesion and Cell Migration," reports on a study performed by Morphotek researchers about the role of endosialin/TEM1 in neovascular biology.
Experimental data showed that endosialin/TEM1, which has been previously shown to be expressed on cells of...
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Source: Immunotherapy Weekly (2007-12-05)
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