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Allergic Reactions

Study helps explain how allergic reactions are triggered

Published in Immunotherapy Weekly, January 30th, 2008

BOSTON –In demonstrating that a group of calcium ion channels play a crucial role in triggering inflammatory responses, researchers at Beth Israel Deaconess Medical Center (BIDMC) have not only solved a longstanding molecular mystery regarding the onset of asthma and allergy symptoms, but have also provided a fundamental discovery regarding the functioning of mast cells. Their findings appear in the January 2008 issue of Nature Immunology.

A group of immune cells found in tissues throughout the body, mast cells were once exclusively known for their role in allergic reactions, according to the study’s lead author Monika Vig, PhD, an investigator in the Department of...

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