Life Sciences

New life sciences research reported from University of Heidelberg, Department of Surgery

Published in Immunotherapy Weekly, January 30th, 2008

A report, 'Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP,' is newly published data in Molecular Immunology. According to a study from Heidelberg, Germany, "Signaling lymphocyte activation molecule (SLAM, CD150) is a co-stimulatory receptor involved in T cell activation. The activity of CD150 is dependent on the intracellular signaling molecule SAP."

"Here, we investigated anti-CD3 activated human lymphocytes, transfected either with CD150-plasmid or with CD150-or SAP-siRNA in cytotoxicity assays against human colon cancer cells in vitro and in a xenograft model (CB/Scid/CrL mice) in vivo. Up-regulation or silencing of CD150 was...

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Source: Immunotherapy Weekly (2008-01-30)

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