Life Sciences
Scientists at University of Paris describe research in life sciences
Published in Immunotherapy Weekly, January 30th, 2008
Data detailed in 'The context of HLA-DR/CD18 complex in the plasma membrane governs HLA-DR-derived signals in activated monocytes' have been presented. "HLA-DR-derived signals in activated monocytes mediate both pro-inflammatory cytokine production and caspase-independent death, and have been postulated to play a role in inflammation and in its resolution, respectively. Herein, using the monocytic/macrophagic human cell line THP-1 primed with IFNgamma (IFNgamma-primed THP-1), we investigated how HLA-DR may integrate both signals," scientists writing in the journal Molecular Immunology report.
"Our inhibition studies demonstrated that if cell death is dependent on...
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Source: Immunotherapy Weekly (2008-01-30)
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