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Type 1 Diabetes
Research from University of Toronto provide new insights into type 1 diabetes
May 21st, 2008
According to a study from Toronto, Canada, "Type 1 diabetes reflects autoimmune destruction of P-cells and peri-islet Schwann cells (pSCs), but the mechanisms of pSC death and the T-cell epitopes involved remain unclear. Primary pSC cultures were generated and used as targets in cytotoxic T-lymphocyte (CTL) assays in NOD mice." "Cognate interaction between pSC and CD8+ T-cells was assessed by transgenic restoration of beta 2-microglobulin (beta 2m) to pSC in NOD.beta 2m(-/-) congenics. I-A(g7) and K-d epitopes in the pSC antigen glial fibrillary acidic protein (GFAP) were identified by peptide mapping or algorithms, respectively, and the latter tested by immunotherapy....
Source: Immunotherapy Weekly (2008-05-21)
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