Immunotherapy Weekly
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Autoimmune Disease
Research from T. Calzascia and co-authors provides new data about autoimmune disease
May 21st, 2008
"There are many inhibitory mechanisms that function at the cellular and molecular levels to maintain tolerance. Despite this, self-reactive clones escape regulatory mechanisms and cause autoimmunity in certain circumstances," researchers in Toronto, Canada report. "We hypothesized that the same mechanisms that permit T cells to expand during homeostatic proliferation may inadvertently promote autoimmunity under certain conditions. One major homeostatic cytokine is IL-7, and studies have linked it or its receptor to the development of multiple sclerosis and other autoimmune diseases. We show in a model of P-islet cell self-reactivity that the transfer of activated...
Source: Immunotherapy Weekly (2008-05-21)
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