Immunotherapy Weekly
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Gene Therapy
Research on gene therapy described by S. Rudel and colleagues
August 20th, 2008
"Small regulatory RNAs including small interfering RNAs (siRNAs), microRNAs (miRNAs), or Piwi interacting RNAs (piRNAs) guide regulation of gene expression in many different organisms. The Argonaute (Ago) protein family constitutes the cellular binding partners of such small RNAs and regulates gene expression on the levels of transcription, mRNA stability, or translation," researchers in Martinsried, Germany report. "Due to the lack of highly specific and potent monoclonal antibodies directed against the different Ago proteins, biochemical analyses such as Ago complex purification and characterization rely on overexpression of tagged Ago proteins. Here, we report the...
Source: Immunotherapy Weekly (2008-08-20)
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