Organ Transplants

Studies from A.G. Lewis and co-researchers in the area of organ transplants published

Published in Immunotherapy Weekly, September 10th, 2008

According to recent research from the United States, "Cadaveric renal transplants suffer frequently from delayed graft function, which is associated with increased risk for long-term graft survival loss. One-third of kidney grafts that are stored in current organ preservation solutions experience delayed graft function, demonstrating the urgent need for improvement."

"Although ischaemic graft injury is complex in nature, complement activation is considered important to the process. Here we show that pharmacological targeting of the complement 5a receptor (C5aR) during cold ischaemia has a protective effect on early kidney graft survival, inflammation and apoptosis in a...

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Source: Immunotherapy Weekly (2008-09-10)

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