Immunotherapy Weekly
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Monoclonal Antibodies
Scientists at Hebrew University discuss research in monoclonal antibodies
September 10th, 2008
"The recently determined crystal structure of NhaA, the Na+/H+ antiporter of Escherichia coli, showed that the previously constructed series of NhaA-alkaline phosphatase (PhoA) fusions correctly predicted the topology of NhaA's 12 transmembrane segments (TMS), with the C- and N-termini pointing to the cytoplasm. Here, we show that these NhaA-PhoA fusions provide an excellent tool for mapping the epitopes of three NhaA-specific conformational monoclonal antibodies (mAbs), of which two drastically inhibit the antiporter," investigators in Jerusalem, Israel report. "By identifying which of the NhaA fusions is bound by the respective mAb, the epitopes were localized to...
Source: Immunotherapy Weekly (2008-09-10)
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